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Asbjørn Mohr Drewes

Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisKonferenceabstrakt i tidsskriftForskningpeer review

Standard

Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis. / Frøkjær, Jens Brøndum; Olesen, Søren Schou; Gram, Mikkel; Yavarian, Yousef; Bouwense, Stefan A W; Wilder-Smith, Oliver; Drewes, Asbjørn Mohr.

I: Pancreatology, Bind 11, Nr. 2, 2011, s. 185.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisKonferenceabstrakt i tidsskriftForskningpeer review

Harvard

Frøkjær, JB, Olesen, SS, Gram, M, Yavarian, Y, Bouwense, SAW, Wilder-Smith, O & Drewes, AM 2011, 'Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis', Pancreatology, bind 11, nr. 2, s. 185.

APA

Frøkjær, J. B., Olesen, S. S., Gram, M., Yavarian, Y., Bouwense, S. A. W., Wilder-Smith, O., & Drewes, A. M. (2011). Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis. Pancreatology, 11(2), 185.

CBE

Frøkjær JB, Olesen SS, Gram M, Yavarian Y, Bouwense SAW, Wilder-Smith O, Drewes AM. 2011. Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis. Pancreatology. 11(2):185.

MLA

Vancouver

Frøkjær JB, Olesen SS, Gram M, Yavarian Y, Bouwense SAW, Wilder-Smith O o.a. Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis. Pancreatology. 2011;11(2):185.

Author

Frøkjær, Jens Brøndum ; Olesen, Søren Schou ; Gram, Mikkel ; Yavarian, Yousef ; Bouwense, Stefan A W ; Wilder-Smith, Oliver ; Drewes, Asbjørn Mohr. / Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis. I: Pancreatology. 2011 ; Bind 11, Nr. 2. s. 185.

Bibtex

@article{f1adf2bb8fce4046886f9acf8897224c,
title = "Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis",
abstract = "Objective In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores. Methods 23 patients with CP pain and 14 controls were studied in a 3T MR scanner. Apparent diffusion coefficient (ADC) (ie, diffusivity of water) and fractional anisotropy (FA) (ie, organisation of fibres) values were assessed in the amygdala, cingulate cortex, insula, prefrontal cortex and secondary sensory cortex. Daily pain scores and the Brief Pain Inventory Short Form were collected 1 week before the investigation. Results In grey matter, patients had increased ADC values in amygdala, cingulate cortex, insula and prefrontal cortex, as well as decreased FA values in cingulate cortex and secondary sensory cortex. In white matter, patients had increased ADC values in insula and prefrontal cortex, and decreased FA values in insula and prefrontal cortex (all p values 0.05). Microstructural changes in cingulate and prefrontal cortices were correlated to patients' clinical pain scores. Conclusion The findings suggest that microstructural changes of the brain accompany pain in CP. The changes are likely to be a consequence of ongoing pain and structural reorganisation of the neuromatrix as also seen in other diseases characterised by chronic pain.",
author = "Fr{\o}kj{\ae}r, {Jens Br{\o}ndum} and Olesen, {S{\o}ren Schou} and Mikkel Gram and Yousef Yavarian and Bouwense, {Stefan A W} and Oliver Wilder-Smith and Drewes, {Asbj{\o}rn Mohr}",
year = "2011",
language = "English",
volume = "11",
pages = "185",
journal = "Pancreatology",
issn = "1424-3903",
publisher = "Elsevier BV",
number = "2",
note = "null ; Conference date: 22-06-2011 Through 25-06-2011",

}

RIS

TY - ABST

T1 - Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis

AU - Frøkjær, Jens Brøndum

AU - Olesen, Søren Schou

AU - Gram, Mikkel

AU - Yavarian, Yousef

AU - Bouwense, Stefan A W

AU - Wilder-Smith, Oliver

AU - Drewes, Asbjørn Mohr

PY - 2011

Y1 - 2011

N2 - Objective In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores. Methods 23 patients with CP pain and 14 controls were studied in a 3T MR scanner. Apparent diffusion coefficient (ADC) (ie, diffusivity of water) and fractional anisotropy (FA) (ie, organisation of fibres) values were assessed in the amygdala, cingulate cortex, insula, prefrontal cortex and secondary sensory cortex. Daily pain scores and the Brief Pain Inventory Short Form were collected 1 week before the investigation. Results In grey matter, patients had increased ADC values in amygdala, cingulate cortex, insula and prefrontal cortex, as well as decreased FA values in cingulate cortex and secondary sensory cortex. In white matter, patients had increased ADC values in insula and prefrontal cortex, and decreased FA values in insula and prefrontal cortex (all p values 0.05). Microstructural changes in cingulate and prefrontal cortices were correlated to patients' clinical pain scores. Conclusion The findings suggest that microstructural changes of the brain accompany pain in CP. The changes are likely to be a consequence of ongoing pain and structural reorganisation of the neuromatrix as also seen in other diseases characterised by chronic pain.

AB - Objective In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores. Methods 23 patients with CP pain and 14 controls were studied in a 3T MR scanner. Apparent diffusion coefficient (ADC) (ie, diffusivity of water) and fractional anisotropy (FA) (ie, organisation of fibres) values were assessed in the amygdala, cingulate cortex, insula, prefrontal cortex and secondary sensory cortex. Daily pain scores and the Brief Pain Inventory Short Form were collected 1 week before the investigation. Results In grey matter, patients had increased ADC values in amygdala, cingulate cortex, insula and prefrontal cortex, as well as decreased FA values in cingulate cortex and secondary sensory cortex. In white matter, patients had increased ADC values in insula and prefrontal cortex, and decreased FA values in insula and prefrontal cortex (all p values 0.05). Microstructural changes in cingulate and prefrontal cortices were correlated to patients' clinical pain scores. Conclusion The findings suggest that microstructural changes of the brain accompany pain in CP. The changes are likely to be a consequence of ongoing pain and structural reorganisation of the neuromatrix as also seen in other diseases characterised by chronic pain.

M3 - Conference abstract in journal

VL - 11

SP - 185

JO - Pancreatology

JF - Pancreatology

SN - 1424-3903

IS - 2

Y2 - 22 June 2011 through 25 June 2011

ER -