Aarhus University Seal / Aarhus Universitets segl

Asbjørn Mohr Drewes

Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis. / Frøkjær, Jens Brøndum; Olesen, Søren Schou; Gram, Mikkel; Yavarian, Yousef; Bouwense, Stefan A W; Wilder-Smith, Oliver; Drewes, Asbjørn Mohr.

I: Gut, Bind 60, Nr. 11, 24.05.2011, s. 1554-62.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Frøkjær, JB, Olesen, SS, Gram, M, Yavarian, Y, Bouwense, SAW, Wilder-Smith, O & Drewes, AM 2011, 'Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis', Gut, bind 60, nr. 11, s. 1554-62. https://doi.org/10.1136/gut.2010.236620

APA

Frøkjær, J. B., Olesen, S. S., Gram, M., Yavarian, Y., Bouwense, S. A. W., Wilder-Smith, O., & Drewes, A. M. (2011). Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis. Gut, 60(11), 1554-62. https://doi.org/10.1136/gut.2010.236620

CBE

Frøkjær JB, Olesen SS, Gram M, Yavarian Y, Bouwense SAW, Wilder-Smith O, Drewes AM. 2011. Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis. Gut. 60(11):1554-62. https://doi.org/10.1136/gut.2010.236620

MLA

Vancouver

Frøkjær JB, Olesen SS, Gram M, Yavarian Y, Bouwense SAW, Wilder-Smith O o.a. Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis. Gut. 2011 maj 24;60(11):1554-62. https://doi.org/10.1136/gut.2010.236620

Author

Frøkjær, Jens Brøndum ; Olesen, Søren Schou ; Gram, Mikkel ; Yavarian, Yousef ; Bouwense, Stefan A W ; Wilder-Smith, Oliver ; Drewes, Asbjørn Mohr. / Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis. I: Gut. 2011 ; Bind 60, Nr. 11. s. 1554-62.

Bibtex

@article{72f6a55e0bf546fba7842e0c937502ee,
title = "Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis",
abstract = "Objective In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores. Methods 23 patients with CP pain and 14 controls were studied in a 3T MR scanner. Apparent diffusion coefficient (ADC) (ie, diffusivity of water) and fractional anisotropy (FA) (ie, organisation of fibres) values were assessed in the amygdala, cingulate cortex, insula, prefrontal cortex and secondary sensory cortex. Daily pain scores and the Brief Pain Inventory Short Form were collected 1 week before the investigation. Results In grey matter, patients had increased ADC values in amygdala, cingulate cortex, insula and prefrontal cortex, as well as decreased FA values in cingulate cortex and secondary sensory cortex. In white matter, patients had increased ADC values in insula and prefrontal cortex, and decreased FA values in insula and prefrontal cortex (all p values 0.05). Microstructural changes in cingulate and prefrontal cortices were correlated to patients' clinical pain scores. Conclusion The findings suggest that microstructural changes of the brain accompany pain in CP. The changes are likely to be a consequence of ongoing pain and structural reorganisation of the neuromatrix as also seen in other diseases characterised by chronic pain.",
author = "Fr{\o}kj{\ae}r, {Jens Br{\o}ndum} and Olesen, {S{\o}ren Schou} and Mikkel Gram and Yousef Yavarian and Bouwense, {Stefan A W} and Oliver Wilder-Smith and Drewes, {Asbj{\o}rn Mohr}",
year = "2011",
month = may,
day = "24",
doi = "10.1136/gut.2010.236620",
language = "English",
volume = "60",
pages = "1554--62",
journal = "Gut",
issn = "0017-5749",
publisher = "B M J Group",
number = "11",

}

RIS

TY - JOUR

T1 - Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis

AU - Frøkjær, Jens Brøndum

AU - Olesen, Søren Schou

AU - Gram, Mikkel

AU - Yavarian, Yousef

AU - Bouwense, Stefan A W

AU - Wilder-Smith, Oliver

AU - Drewes, Asbjørn Mohr

PY - 2011/5/24

Y1 - 2011/5/24

N2 - Objective In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores. Methods 23 patients with CP pain and 14 controls were studied in a 3T MR scanner. Apparent diffusion coefficient (ADC) (ie, diffusivity of water) and fractional anisotropy (FA) (ie, organisation of fibres) values were assessed in the amygdala, cingulate cortex, insula, prefrontal cortex and secondary sensory cortex. Daily pain scores and the Brief Pain Inventory Short Form were collected 1 week before the investigation. Results In grey matter, patients had increased ADC values in amygdala, cingulate cortex, insula and prefrontal cortex, as well as decreased FA values in cingulate cortex and secondary sensory cortex. In white matter, patients had increased ADC values in insula and prefrontal cortex, and decreased FA values in insula and prefrontal cortex (all p values 0.05). Microstructural changes in cingulate and prefrontal cortices were correlated to patients' clinical pain scores. Conclusion The findings suggest that microstructural changes of the brain accompany pain in CP. The changes are likely to be a consequence of ongoing pain and structural reorganisation of the neuromatrix as also seen in other diseases characterised by chronic pain.

AB - Objective In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores. Methods 23 patients with CP pain and 14 controls were studied in a 3T MR scanner. Apparent diffusion coefficient (ADC) (ie, diffusivity of water) and fractional anisotropy (FA) (ie, organisation of fibres) values were assessed in the amygdala, cingulate cortex, insula, prefrontal cortex and secondary sensory cortex. Daily pain scores and the Brief Pain Inventory Short Form were collected 1 week before the investigation. Results In grey matter, patients had increased ADC values in amygdala, cingulate cortex, insula and prefrontal cortex, as well as decreased FA values in cingulate cortex and secondary sensory cortex. In white matter, patients had increased ADC values in insula and prefrontal cortex, and decreased FA values in insula and prefrontal cortex (all p values 0.05). Microstructural changes in cingulate and prefrontal cortices were correlated to patients' clinical pain scores. Conclusion The findings suggest that microstructural changes of the brain accompany pain in CP. The changes are likely to be a consequence of ongoing pain and structural reorganisation of the neuromatrix as also seen in other diseases characterised by chronic pain.

U2 - 10.1136/gut.2010.236620

DO - 10.1136/gut.2010.236620

M3 - Journal article

C2 - 21610272

VL - 60

SP - 1554

EP - 1562

JO - Gut

JF - Gut

SN - 0017-5749

IS - 11

ER -