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Asbjørn Mohr Drewes

A new distensibility technique to measure sphincter of Oddi function

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A new distensibility technique to measure sphincter of Oddi function. / Kunwald, P; Drewes, A M; Kjær, Daniel Willy; Gravesen, F H; McMahon, B P; Madácsy, L; Funch-Jensen, P; Gregersen, H.

I: Neurogastroenterology and Motility, Bind 22, Nr. 9, 2010, s. 978-83.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Kunwald, P, Drewes, AM, Kjær, DW, Gravesen, FH, McMahon, BP, Madácsy, L, Funch-Jensen, P & Gregersen, H 2010, 'A new distensibility technique to measure sphincter of Oddi function', Neurogastroenterology and Motility, bind 22, nr. 9, s. 978-83. https://doi.org/10.1111/j.1365-2982.2010.01531.x

APA

Kunwald, P., Drewes, A. M., Kjær, D. W., Gravesen, F. H., McMahon, B. P., Madácsy, L., Funch-Jensen, P., & Gregersen, H. (2010). A new distensibility technique to measure sphincter of Oddi function. Neurogastroenterology and Motility, 22(9), 978-83. https://doi.org/10.1111/j.1365-2982.2010.01531.x

CBE

MLA

Vancouver

Author

Kunwald, P ; Drewes, A M ; Kjær, Daniel Willy ; Gravesen, F H ; McMahon, B P ; Madácsy, L ; Funch-Jensen, P ; Gregersen, H. / A new distensibility technique to measure sphincter of Oddi function. I: Neurogastroenterology and Motility. 2010 ; Bind 22, Nr. 9. s. 978-83.

Bibtex

@article{19d8fe807f6511df8c1a000ea68e967b,
title = "A new distensibility technique to measure sphincter of Oddi function",
abstract = "Abstract Background Evaluation of the biliary tract is important in physiological, pathophysiological, and clinical studies. Although the sphincter of Oddi (SO) can be evaluated with manometry, this technique has several limitations. This may explain the difficulties in identifying pathophysiological mechanisms for dysfunction of the SO and in identifying patients who may benefit from certain therapies. To encompass problems with manometry, methods such as the functional lumen imaging probe (FLIP) technique have been developed to study GI sphincters. This study set about miniaturising the FLIP probe and validating it for measurements in the SO. In order to get a better physiological understanding of the SO the aims were to show the sphincter profile in vivo and motility patterns of SO in pilot studies using volunteers that were experiencing biliary type pain but had normal SO manometry. Methods The SO probe was constructed to measure eight cross-sectional areas (CSA) along a length of 25 mm inside a saline-filled bag. To validate the technique for profiling the SO, six perspex cylinders with different CSAs were measured nine times to assess reproducibility and accuracy. Key Results Reproducibility and accuracy for these measurements were good. The probe performed well in bench tests and was therefore tested in four humans. The data indicated that it was possible to make distensions in the human SO and that a geometric sphincter profile could be obtained. Conclusions & Inferences The probe will in future studies be tested for diagnostic purposes related to sphincter of Oddi diseases.",
author = "P Kunwald and Drewes, {A M} and Kj{\ae}r, {Daniel Willy} and Gravesen, {F H} and McMahon, {B P} and L Mad{\'a}csy and P Funch-Jensen and H Gregersen",
year = "2010",
doi = "10.1111/j.1365-2982.2010.01531.x",
language = "English",
volume = "22",
pages = "978--83",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - A new distensibility technique to measure sphincter of Oddi function

AU - Kunwald, P

AU - Drewes, A M

AU - Kjær, Daniel Willy

AU - Gravesen, F H

AU - McMahon, B P

AU - Madácsy, L

AU - Funch-Jensen, P

AU - Gregersen, H

PY - 2010

Y1 - 2010

N2 - Abstract Background Evaluation of the biliary tract is important in physiological, pathophysiological, and clinical studies. Although the sphincter of Oddi (SO) can be evaluated with manometry, this technique has several limitations. This may explain the difficulties in identifying pathophysiological mechanisms for dysfunction of the SO and in identifying patients who may benefit from certain therapies. To encompass problems with manometry, methods such as the functional lumen imaging probe (FLIP) technique have been developed to study GI sphincters. This study set about miniaturising the FLIP probe and validating it for measurements in the SO. In order to get a better physiological understanding of the SO the aims were to show the sphincter profile in vivo and motility patterns of SO in pilot studies using volunteers that were experiencing biliary type pain but had normal SO manometry. Methods The SO probe was constructed to measure eight cross-sectional areas (CSA) along a length of 25 mm inside a saline-filled bag. To validate the technique for profiling the SO, six perspex cylinders with different CSAs were measured nine times to assess reproducibility and accuracy. Key Results Reproducibility and accuracy for these measurements were good. The probe performed well in bench tests and was therefore tested in four humans. The data indicated that it was possible to make distensions in the human SO and that a geometric sphincter profile could be obtained. Conclusions & Inferences The probe will in future studies be tested for diagnostic purposes related to sphincter of Oddi diseases.

AB - Abstract Background Evaluation of the biliary tract is important in physiological, pathophysiological, and clinical studies. Although the sphincter of Oddi (SO) can be evaluated with manometry, this technique has several limitations. This may explain the difficulties in identifying pathophysiological mechanisms for dysfunction of the SO and in identifying patients who may benefit from certain therapies. To encompass problems with manometry, methods such as the functional lumen imaging probe (FLIP) technique have been developed to study GI sphincters. This study set about miniaturising the FLIP probe and validating it for measurements in the SO. In order to get a better physiological understanding of the SO the aims were to show the sphincter profile in vivo and motility patterns of SO in pilot studies using volunteers that were experiencing biliary type pain but had normal SO manometry. Methods The SO probe was constructed to measure eight cross-sectional areas (CSA) along a length of 25 mm inside a saline-filled bag. To validate the technique for profiling the SO, six perspex cylinders with different CSAs were measured nine times to assess reproducibility and accuracy. Key Results Reproducibility and accuracy for these measurements were good. The probe performed well in bench tests and was therefore tested in four humans. The data indicated that it was possible to make distensions in the human SO and that a geometric sphincter profile could be obtained. Conclusions & Inferences The probe will in future studies be tested for diagnostic purposes related to sphincter of Oddi diseases.

U2 - 10.1111/j.1365-2982.2010.01531.x

DO - 10.1111/j.1365-2982.2010.01531.x

M3 - Journal article

C2 - 20553561

VL - 22

SP - 978

EP - 983

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

IS - 9

ER -