Department of Biomedicine

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Asad Jan

Adjunkt

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Asad Jan

Adjunkt

  • Institut for Biomedicin - Forskning og uddannelse, Skou-bygningen
Adressetype: Postaddresse.
Høegh-Guldbergs Gade 10
1116
8000
Aarhus C
Danmark

E-mail: ajan@biomed.au.dk

Kvalifikationer

Neuroscience, PhD, Amyloid toxicity in Alzheimer's disease, Swiss Federal Institute of Technology Lausanne

1 jul. 2006 → 29 jul. 2010

Dimissionsdato: 29 jul. 2010

Clinical Medicine, MBBS

30 sep. 2001 → 31 okt. 2004

Dimissionsdato: 1 feb. 2005

Ansættelse

Adjunkt

Institut for Biomedicin - Forskning og uddannelse, Skou-bygningen

Aarhus Universitet

Aarhus C, Danmark

2 jan. 2022 → nu

Postdoc

Institut for Biomedicin - Forskning og uddannelse, Vest

Aarhus Universitet

Aarhus C, Danmark

11 sep. 2019 → 2 jan. 2022

Postdoc

DANDRITE - Jensen Group

Aarhus Universitet

Aarhus C, Danmark

28 sep. 2017 → 2 jan. 2022

Postdoc

Aarhus Institute of Advanced Studies

Aarhus Universitet

Aarhus C, Danmark

20 sep. 2017 → 1 sep. 2019

Postdoc

Institut for Biomedicin - Forskning og uddannelse, Vest

Aarhus Universitet

Aarhus C, Danmark

28 sep. 2017 → 1 sep. 2019

Postdoc

Aarhus Institute of Advanced Studies

Aarhus Universitet

Aarhus C, Danmark

29 aug. 2017 → 5 sep. 2017

Publikationer

GLP-1-Receptor Agonists in Neurodegeneration: Neurovascular Unit in the Spotlight

Monti, G., Gomes Moreira, D., Richner, M., Mutsaers, H. A. M., Ferreira, N. & Jan, A., jul. 2022, I: Cells. 11, 13, 2023.

Recombinant adeno-associated virus mediated gene delivery in the extracranial nervous system of adult mice by direct nerve immersion

Richner, M., Gonçalves, N. P., Jensen, P. H., Nyengaard, J. R., Vægter, C. B. & Jan, A., mar. 2022, I: STAR Protocols. 3, 1, 15 s., 101181.

The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease: Update on Models and Hypotheses

Jan, A., Gonçalves, N. P., Vaegter, C. B., Jensen, P. H. & Ferreira, N., aug. 2021, I: International Journal of Molecular Sciences . 22, 15, 23 s., 8338.

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

Delaidelli, A., Richner, M., Jiang, L., van der Laan, A., Bergholdt Jul Christiansen, I., Ferreira, N., Nyengaard, J. R., Vægter, C. B., Jensen, P. H., Mackenzie, I. R., Sorensen, P. H. & Jan, A., jun. 2021, I: Acta Neuropathologica Communications. 9, 1, 16 s., 105.

Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy

Ferreira, N., Richner, M., van der Laan, A., Bergholdt Jul Christiansen, I., Vægter, C. B., Nyengaard, J. R., Halliday, G. M., Weiss, J., Giasson, B. I., Mackenzie, I. R., Jensen, P. H. & Jan, A., maj 2021, I: Brain Communications. 3, 2, 17 s., fcab104.

Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain

Ferreira, N., Gonçalves, N. P., Jan, A., Jensen, N. M., van der Laan, A., Mohseni, S., Vægter, C. B. & Jensen, P. H., feb. 2021, I: Acta Neuropathologica Communications. 9, 31.

Gene Transfer in Rodent Nervous Tissue Following Hindlimb Intramuscular Delivery of Recombinant Adeno-Associated Virus Serotypes AAV2/6, AAV2/8, and AAV2/9

Asad, J., Richner, M., Vægter, C. B., Nyengaard, J. R. & Jensen, P. H., nov. 2019, I: Neuroscience Insights. 14, November-December, s. 1-12

Translational control in brain pathologies: biological significance and therapeutic opportunities

Delaidelli, A., Jan, A., Herms, J. & Sorensen, P. H., apr. 2019, I: Acta Neuropathologica. 137, 4, s. 535-555 21 s.

Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

Jan, A., Jansonius, B., Delaidelli, A., Bhanshali, F., An, Y. A., Ferreira, N., Smits, L. M., Negri, G. L., Schwamborn, J. C., Jensen, P. H., Mackenzie, I. R., Taubert, S. & Sorensen, P. H., 2018, I: Acta Neuropathologica Communications. 6, 1, 17 s., 54.

MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation

Delaidelli, A., Negri, G. L., Jan, A., Jansonius, B., El-Naggar, A., Lim, J. K. M., Khan, D., Zarni Oo, H., Carnie, C. J., Remke, M., Maris, J. M., Leprivier, G. & Sorensen, P. H., sep. 2017, I: Cell Death and Differentiation. 24, 9, s. 1564-1576 13 s.

eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response

Jan, A., Jansonius, B., Delaidelli, A., Somasekharan, S. P., Bhanshali, F., Vandal, M., Negri, G. L., Moerman, D., MacKenzie, I., Calon, F., Hayden, M. R., Taubert, S. & Sorensen, P. H., jan. 2017, I: Acta Neuropathologica. 133, 1, s. 101-119 19 s.

Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression. [Corrected]

Jan, A., Karasinska, J. M., Kang, M. H., de Haan, W., Ruddle, P., Kaur, A., Connolly, C., Leavitt, B. R., Sorensen, P. H. & Hayden, M. R., 26 jun. 2015, I: Neuroscience Letters. 598, s. 66-72 7 s.

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation

Kroth, H., Ansaloni, A., Varisco, Y., Jan, A., Sreenivasachary, N., Rezaei-Ghaleh, N., Giriens, V., Lohmann, S., López-Deber, M. P., Adolfsson, O., Pihlgren, M., Paganetti, P., Froestl, W., Nagel-Steger, L., Willbold, D., Schrader, T., Zweckstetter, M., Pfeifer, A., Lashuel, H. A. & Muhs, A., 2012, I: The Journal of biological chemistry. 287, 41, s. 34786-800 15 s.

Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches

Jan, A. & Lashuel, H. A., 2012, I: Methods in molecular biology (Clifton, N.J.). 849, s. 227-43 17 s.

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

Jan, A., Adolfsson, O., Allaman, I., Buccarello, A-L., Magistretti, P. J., Pfeifer, A., Muhs, A. & Lashuel, H. A., 11 mar. 2011, I: The Journal of biological chemistry. 286, 10, s. 8585-96 12 s.

Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research

Jan, A., Hartley, D. M. & Lashuel, H. A., jun. 2010, I: Nature Protocols (Print). 5, 6, s. 1186-209 24 s.

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

Jan, A., Gokce, O., Luthi-Carter, R. & Lashuel, H. A., 2008, I: Journal of Biological Chemistry. 283, 42, s. 28176-89 14 s.

Presse/medie

“Jekyll and Hyde” enzyme has potential for countering cancer and Alzheimer’s

Asad Jan

24/10/2016

1 Mediebidrag