The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes

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The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes. / Drago, Antonio; Crisafulli, Concetta; Sidoti, Antonina; Serretti, Alessandro.

I: Progress in Neurobiology, Bind 94, Nr. 4, 01.09.2011, s. 418-60.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Drago, Antonio ; Crisafulli, Concetta ; Sidoti, Antonina ; Serretti, Alessandro. / The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes. I: Progress in Neurobiology. 2011 ; Bind 94, Nr. 4. s. 418-60.

Bibtex

@article{fe70e5229e2c4296a917ce566d14ac2e,
title = "The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes",
abstract = "The glutamatergic pathway has been consistently involved in the physiopathology of depressive disorder. However a complete dissection and integration of its role in the context of other known mechanisms is lacking. We summarized and integrated the evidence of various levels of interaction between glutamatergic and monoaminergic pathways (see videos). We identified six molecular pathways, some of which with specific regional distribution within the brain. From the six pathways we identified the key proteins and their coding genes, we then provided a detailed list of possible candidates with practical suggestions for association studies planning.",
keywords = "Animals, Brain, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Cyclic AMP-Dependent Protein Kinases, Depressive Disorder, Dopamine, Excitatory Amino Acid Agents, Glutamic Acid, Humans, Mitogen-Activated Protein Kinases, Neural Pathways, Nitric Oxide, Norepinephrine, Phenotype, Protein Kinase C, Receptors, Dopamine, Serotonin, Signal Transduction",
author = "Antonio Drago and Concetta Crisafulli and Antonina Sidoti and Alessandro Serretti",
note = "Copyright {\textcopyright} 2011 Elsevier Ltd. All rights reserved.",
year = "2011",
month = sep,
day = "1",
doi = "10.1016/j.pneurobio.2011.05.009",
language = "English",
volume = "94",
pages = "418--60",
journal = "Progress in Neurobiology",
issn = "0301-0082",
publisher = "Pergamon Press",
number = "4",

}

RIS

TY - JOUR

T1 - The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes

AU - Drago, Antonio

AU - Crisafulli, Concetta

AU - Sidoti, Antonina

AU - Serretti, Alessandro

N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.

PY - 2011/9/1

Y1 - 2011/9/1

N2 - The glutamatergic pathway has been consistently involved in the physiopathology of depressive disorder. However a complete dissection and integration of its role in the context of other known mechanisms is lacking. We summarized and integrated the evidence of various levels of interaction between glutamatergic and monoaminergic pathways (see videos). We identified six molecular pathways, some of which with specific regional distribution within the brain. From the six pathways we identified the key proteins and their coding genes, we then provided a detailed list of possible candidates with practical suggestions for association studies planning.

AB - The glutamatergic pathway has been consistently involved in the physiopathology of depressive disorder. However a complete dissection and integration of its role in the context of other known mechanisms is lacking. We summarized and integrated the evidence of various levels of interaction between glutamatergic and monoaminergic pathways (see videos). We identified six molecular pathways, some of which with specific regional distribution within the brain. From the six pathways we identified the key proteins and their coding genes, we then provided a detailed list of possible candidates with practical suggestions for association studies planning.

KW - Animals

KW - Brain

KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2

KW - Cyclic AMP-Dependent Protein Kinases

KW - Depressive Disorder

KW - Dopamine

KW - Excitatory Amino Acid Agents

KW - Glutamic Acid

KW - Humans

KW - Mitogen-Activated Protein Kinases

KW - Neural Pathways

KW - Nitric Oxide

KW - Norepinephrine

KW - Phenotype

KW - Protein Kinase C

KW - Receptors, Dopamine

KW - Serotonin

KW - Signal Transduction

U2 - 10.1016/j.pneurobio.2011.05.009

DO - 10.1016/j.pneurobio.2011.05.009

M3 - Journal article

C2 - 21723912

VL - 94

SP - 418

EP - 460

JO - Progress in Neurobiology

JF - Progress in Neurobiology

SN - 0301-0082

IS - 4

ER -