Antonio Drago

The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Chi-Un Pae
  • ,
  • Antonio Drago
  • Jung-Jin Kim
  • ,
  • Laura Mandelli
  • ,
  • Diana De Ronchi
  • ,
  • Alessandro Serretti

We previously investigated a group of single-nucleotide polymorphisms of a set of genes coding for heat shock proteins (HSPA1A, HSPA1B and HSPA1L) and found a significant association between one HSPA1B variation and schizophrenia (SZ). We now report an association between a set of variations (rs2227956, rs2075799, rs1043618, rs562047 and rs539689) within the same genes and a larger sample of schizophrenic inpatients. A single variation, rs539689 (HSPA1B), was found to be marginally associated with Positive and Negative Syndrome Scale (PANSS) positive scores at discharge, and haplotype analysis revealed a significant association between improvement in PANSS scores with both A-C-G-G and A-C-G-G haplotypes. These findings further support a role of heat shock proteins in the pathophysiology of SZ.

OriginalsprogEngelsk
TidsskriftNeuropsychobiology
Vol/bind59
Nummer3
Sider (fra-til)135-41
Antal sider7
ISSN0302-282X
DOI
StatusUdgivet - 2009

Se relationer på Aarhus Universitet Citationsformater

ID: 99387784