TAAR6 variations possibly associated with antidepressant response and suicidal behavior

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TAAR6 variations possibly associated with antidepressant response and suicidal behavior. / Pae, Chi-Un; Drago, Antonio; Kim, Jung-Jin; Patkar, Ashwin A; Jun, Tae-Youn; De Ronchi, Diana; Serretti, Alessandro.

I: Psychiatry Research, Bind 180, Nr. 1, 30.11.2010, s. 20-4.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Pae, C-U, Drago, A, Kim, J-J, Patkar, AA, Jun, T-Y, De Ronchi, D & Serretti, A 2010, 'TAAR6 variations possibly associated with antidepressant response and suicidal behavior', Psychiatry Research, bind 180, nr. 1, s. 20-4. https://doi.org/10.1016/j.psychres.2009.08.007

APA

Pae, C-U., Drago, A., Kim, J-J., Patkar, A. A., Jun, T-Y., De Ronchi, D., & Serretti, A. (2010). TAAR6 variations possibly associated with antidepressant response and suicidal behavior. Psychiatry Research, 180(1), 20-4. https://doi.org/10.1016/j.psychres.2009.08.007

CBE

Pae C-U, Drago A, Kim J-J, Patkar AA, Jun T-Y, De Ronchi D, Serretti A. 2010. TAAR6 variations possibly associated with antidepressant response and suicidal behavior. Psychiatry Research. 180(1):20-4. https://doi.org/10.1016/j.psychres.2009.08.007

MLA

Vancouver

Pae C-U, Drago A, Kim J-J, Patkar AA, Jun T-Y, De Ronchi D o.a. TAAR6 variations possibly associated with antidepressant response and suicidal behavior. Psychiatry Research. 2010 nov. 30;180(1):20-4. https://doi.org/10.1016/j.psychres.2009.08.007

Author

Pae, Chi-Un ; Drago, Antonio ; Kim, Jung-Jin ; Patkar, Ashwin A ; Jun, Tae-Youn ; De Ronchi, Diana ; Serretti, Alessandro. / TAAR6 variations possibly associated with antidepressant response and suicidal behavior. I: Psychiatry Research. 2010 ; Bind 180, Nr. 1. s. 20-4.

Bibtex

@article{8f7ce7ae4b124c468237154c40af186a,
title = "TAAR6 variations possibly associated with antidepressant response and suicidal behavior",
abstract = "Trace amines are putative regulatory elements in the brain whose activity may be relevant to the pathophysiology of depressive episodes. TAAR6 is an orphan receptor probably associated with trace amines. Its genetic variations have been associated with bipolar and schizophrenic disorders. In this study we investigated for the first time the possible association between a set of TAAR6 genetic variations (rs7452939; rs4305745; rs6903874; rs6937506; and rs8192625) with clinical features of depression including antidepressant treatment response in a sample of 187 depressive patients all of Korean origins. rs6903874 T/T carriers had a statistically significant better improvement, and rs6937506 C/C genotype was found to be more frequent in patients without a history of suicide attempt (incomplete or unsuccessful suicide). Haplotype analyses confirmed the association with suicide attempt behavior being haplotype G-T at SNPs rs7452939 and rs6937506 at risk of suicide. These results suggest a possible role of TAAR6 in antidepressant response and suicide behavior in patients with depressive disorder. Heterogeneity of treatment, possible stratification bias not controlled by the statistical analyses, and the risk of false-positive finding mandate further analysis in this direction.",
keywords = "Adult, Analysis of Variance, Antidepressive Agents, Cell Cycle Proteins, Depressive Disorder, Female, Haplotypes, Humans, Male, Middle Aged, Nuclear Proteins, Polymorphism, Single Nucleotide, Suicide",
author = "Chi-Un Pae and Antonio Drago and Jung-Jin Kim and Patkar, {Ashwin A} and Tae-Youn Jun and {De Ronchi}, Diana and Alessandro Serretti",
note = "Copyright {\textcopyright} 2009 Elsevier Ltd. All rights reserved.",
year = "2010",
month = nov,
day = "30",
doi = "10.1016/j.psychres.2009.08.007",
language = "English",
volume = "180",
pages = "20--4",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - TAAR6 variations possibly associated with antidepressant response and suicidal behavior

AU - Pae, Chi-Un

AU - Drago, Antonio

AU - Kim, Jung-Jin

AU - Patkar, Ashwin A

AU - Jun, Tae-Youn

AU - De Ronchi, Diana

AU - Serretti, Alessandro

N1 - Copyright © 2009 Elsevier Ltd. All rights reserved.

PY - 2010/11/30

Y1 - 2010/11/30

N2 - Trace amines are putative regulatory elements in the brain whose activity may be relevant to the pathophysiology of depressive episodes. TAAR6 is an orphan receptor probably associated with trace amines. Its genetic variations have been associated with bipolar and schizophrenic disorders. In this study we investigated for the first time the possible association between a set of TAAR6 genetic variations (rs7452939; rs4305745; rs6903874; rs6937506; and rs8192625) with clinical features of depression including antidepressant treatment response in a sample of 187 depressive patients all of Korean origins. rs6903874 T/T carriers had a statistically significant better improvement, and rs6937506 C/C genotype was found to be more frequent in patients without a history of suicide attempt (incomplete or unsuccessful suicide). Haplotype analyses confirmed the association with suicide attempt behavior being haplotype G-T at SNPs rs7452939 and rs6937506 at risk of suicide. These results suggest a possible role of TAAR6 in antidepressant response and suicide behavior in patients with depressive disorder. Heterogeneity of treatment, possible stratification bias not controlled by the statistical analyses, and the risk of false-positive finding mandate further analysis in this direction.

AB - Trace amines are putative regulatory elements in the brain whose activity may be relevant to the pathophysiology of depressive episodes. TAAR6 is an orphan receptor probably associated with trace amines. Its genetic variations have been associated with bipolar and schizophrenic disorders. In this study we investigated for the first time the possible association between a set of TAAR6 genetic variations (rs7452939; rs4305745; rs6903874; rs6937506; and rs8192625) with clinical features of depression including antidepressant treatment response in a sample of 187 depressive patients all of Korean origins. rs6903874 T/T carriers had a statistically significant better improvement, and rs6937506 C/C genotype was found to be more frequent in patients without a history of suicide attempt (incomplete or unsuccessful suicide). Haplotype analyses confirmed the association with suicide attempt behavior being haplotype G-T at SNPs rs7452939 and rs6937506 at risk of suicide. These results suggest a possible role of TAAR6 in antidepressant response and suicide behavior in patients with depressive disorder. Heterogeneity of treatment, possible stratification bias not controlled by the statistical analyses, and the risk of false-positive finding mandate further analysis in this direction.

KW - Adult

KW - Analysis of Variance

KW - Antidepressive Agents

KW - Cell Cycle Proteins

KW - Depressive Disorder

KW - Female

KW - Haplotypes

KW - Humans

KW - Male

KW - Middle Aged

KW - Nuclear Proteins

KW - Polymorphism, Single Nucleotide

KW - Suicide

U2 - 10.1016/j.psychres.2009.08.007

DO - 10.1016/j.psychres.2009.08.007

M3 - Journal article

C2 - 20493543

VL - 180

SP - 20

EP - 24

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 1

ER -