PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway

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Standard

PPP3CC gene : a putative modulator of antidepressant response through the B-cell receptor signaling pathway. / Fabbri, C; Marsano, A; Albani, D; Chierchia, A; Calati, R; Drago, A; Crisafulli, C; Calabrò, M; Kasper, S; Lanzenberger, R; Zohar, J; Juven-Wetzler, A; Souery, D; Montgomery, S; Mendlewicz, J; Serretti, A.

I: Pharmacogenomics Journal, Bind 14, Nr. 5, 2014, s. 463-72.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Fabbri, C, Marsano, A, Albani, D, Chierchia, A, Calati, R, Drago, A, Crisafulli, C, Calabrò, M, Kasper, S, Lanzenberger, R, Zohar, J, Juven-Wetzler, A, Souery, D, Montgomery, S, Mendlewicz, J & Serretti, A 2014, 'PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway', Pharmacogenomics Journal, bind 14, nr. 5, s. 463-72. https://doi.org/10.1038/tpj.2014.15

APA

Fabbri, C., Marsano, A., Albani, D., Chierchia, A., Calati, R., Drago, A., Crisafulli, C., Calabrò, M., Kasper, S., Lanzenberger, R., Zohar, J., Juven-Wetzler, A., Souery, D., Montgomery, S., Mendlewicz, J., & Serretti, A. (2014). PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway. Pharmacogenomics Journal, 14(5), 463-72. https://doi.org/10.1038/tpj.2014.15

CBE

Fabbri C, Marsano A, Albani D, Chierchia A, Calati R, Drago A, Crisafulli C, Calabrò M, Kasper S, Lanzenberger R, Zohar J, Juven-Wetzler A, Souery D, Montgomery S, Mendlewicz J, Serretti A. 2014. PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway. Pharmacogenomics Journal. 14(5):463-72. https://doi.org/10.1038/tpj.2014.15

MLA

Vancouver

Fabbri C, Marsano A, Albani D, Chierchia A, Calati R, Drago A o.a. PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway. Pharmacogenomics Journal. 2014;14(5):463-72. https://doi.org/10.1038/tpj.2014.15

Author

Fabbri, C ; Marsano, A ; Albani, D ; Chierchia, A ; Calati, R ; Drago, A ; Crisafulli, C ; Calabrò, M ; Kasper, S ; Lanzenberger, R ; Zohar, J ; Juven-Wetzler, A ; Souery, D ; Montgomery, S ; Mendlewicz, J ; Serretti, A. / PPP3CC gene : a putative modulator of antidepressant response through the B-cell receptor signaling pathway. I: Pharmacogenomics Journal. 2014 ; Bind 14, Nr. 5. s. 463-72.

Bibtex

@article{8681681a878143899e2808e4dcdc7f83,
title = "PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway",
abstract = "Antidepressant pharmacogenetics represents a stimulating, but often discouraging field. The present study proposes a combination of several methodologies across three independent samples. Genes belonging to monoamine, neuroplasticity, circadian rhythm and transcription factor pathways were investigated in two samples (n=369 and 88) with diagnosis of major depression who were treated with antidepressants. Phenotypes were response, remission and treatment-resistant depression. Logistic regression including appropriate covariates was performed. Genes associated with outcomes were investigated in the STAR*D (Sequenced Treatment Alternatives to Relieve Depression) genome-wide study (n=1861). Top genes were further studied through a pathway analysis. In both original samples, markers associated with outcomes were concentrated in the PPP3CC gene. Other interesting findings were particularly in the HTR2A gene in one original sample and the STAR*D. The B-cell receptor signaling pathway proved to be the putative mediator of PPP3CC's effect on antidepressant response (P=0.03). Among innovative candidates, PPP3CC, involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation.",
keywords = "Antidepressive Agents, Calcineurin, Depression, Humans, Receptors, Antigen, B-Cell, Signal Transduction",
author = "C Fabbri and A Marsano and D Albani and A Chierchia and R Calati and A Drago and C Crisafulli and M Calabr{\`o} and S Kasper and R Lanzenberger and J Zohar and A Juven-Wetzler and D Souery and S Montgomery and J Mendlewicz and A Serretti",
year = "2014",
doi = "10.1038/tpj.2014.15",
language = "English",
volume = "14",
pages = "463--72",
journal = "Pharmacogenomics Journal",
issn = "1470-269X",
publisher = "Nature Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - PPP3CC gene

T2 - a putative modulator of antidepressant response through the B-cell receptor signaling pathway

AU - Fabbri, C

AU - Marsano, A

AU - Albani, D

AU - Chierchia, A

AU - Calati, R

AU - Drago, A

AU - Crisafulli, C

AU - Calabrò, M

AU - Kasper, S

AU - Lanzenberger, R

AU - Zohar, J

AU - Juven-Wetzler, A

AU - Souery, D

AU - Montgomery, S

AU - Mendlewicz, J

AU - Serretti, A

PY - 2014

Y1 - 2014

N2 - Antidepressant pharmacogenetics represents a stimulating, but often discouraging field. The present study proposes a combination of several methodologies across three independent samples. Genes belonging to monoamine, neuroplasticity, circadian rhythm and transcription factor pathways were investigated in two samples (n=369 and 88) with diagnosis of major depression who were treated with antidepressants. Phenotypes were response, remission and treatment-resistant depression. Logistic regression including appropriate covariates was performed. Genes associated with outcomes were investigated in the STAR*D (Sequenced Treatment Alternatives to Relieve Depression) genome-wide study (n=1861). Top genes were further studied through a pathway analysis. In both original samples, markers associated with outcomes were concentrated in the PPP3CC gene. Other interesting findings were particularly in the HTR2A gene in one original sample and the STAR*D. The B-cell receptor signaling pathway proved to be the putative mediator of PPP3CC's effect on antidepressant response (P=0.03). Among innovative candidates, PPP3CC, involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation.

AB - Antidepressant pharmacogenetics represents a stimulating, but often discouraging field. The present study proposes a combination of several methodologies across three independent samples. Genes belonging to monoamine, neuroplasticity, circadian rhythm and transcription factor pathways were investigated in two samples (n=369 and 88) with diagnosis of major depression who were treated with antidepressants. Phenotypes were response, remission and treatment-resistant depression. Logistic regression including appropriate covariates was performed. Genes associated with outcomes were investigated in the STAR*D (Sequenced Treatment Alternatives to Relieve Depression) genome-wide study (n=1861). Top genes were further studied through a pathway analysis. In both original samples, markers associated with outcomes were concentrated in the PPP3CC gene. Other interesting findings were particularly in the HTR2A gene in one original sample and the STAR*D. The B-cell receptor signaling pathway proved to be the putative mediator of PPP3CC's effect on antidepressant response (P=0.03). Among innovative candidates, PPP3CC, involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation.

KW - Antidepressive Agents

KW - Calcineurin

KW - Depression

KW - Humans

KW - Receptors, Antigen, B-Cell

KW - Signal Transduction

U2 - 10.1038/tpj.2014.15

DO - 10.1038/tpj.2014.15

M3 - Journal article

C2 - 24709691

VL - 14

SP - 463

EP - 472

JO - Pharmacogenomics Journal

JF - Pharmacogenomics Journal

SN - 1470-269X

IS - 5

ER -