Pharmacogenetics of lithium long-term treatment: focus on initiation and adaptation mechanisms

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Pharmacogenetics of lithium long-term treatment : focus on initiation and adaptation mechanisms. / Serretti, Alessandro; Drago, Antonio.

I: Neuropsychobiology, Bind 62, Nr. 1, 2010, s. 61-71.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Serretti, Alessandro ; Drago, Antonio. / Pharmacogenetics of lithium long-term treatment : focus on initiation and adaptation mechanisms. I: Neuropsychobiology. 2010 ; Bind 62, Nr. 1. s. 61-71.

Bibtex

@article{89b7ccc0902643b9b5ae1447f5fff30b,
title = "Pharmacogenetics of lithium long-term treatment: focus on initiation and adaptation mechanisms",
abstract = "Bipolar disorder is a common disease with a high impact in terms of personal suffering and socioeconomic burden. The disentanglement of the molecular deregulations that cause this disorder is pivotal to the understanding of its etiology. This will hopefully cast the engineering of new and more favorable treatments. New insights in the molecular aspects of bipolar disorder may be brought by the understanding of the pharmacodynamics of lithium, the first-line treatment for this disease. The mechanisms by which lithium exerts its activity in the central nervous system are not fully clarified: it is hypothesized that lithium may drive acute molecular events whose activation over time triggers long-lasting modifications in critical neuronal nets. These events are associated with long-lasting changes in the expression profile of genes in neurons that are embedded in these crucial nets. The molecular events that are acutely and chronically triggered by lithium will be reviewed here and matched with the evidence that arises from the pharmacogenetics investigations. Moreover, the pharmacogenetics reports that are not strictly associated with the mechanisms that are thought to be acutely and chronically elicited by lithium will be included in the final part of the paper.",
keywords = "Animals, Antimanic Agents, Bipolar Disorder, Humans, Lithium Compounds, Time Factors",
author = "Alessandro Serretti and Antonio Drago",
note = "Copyright 2010 S. Karger AG, Basel.",
year = "2010",
doi = "10.1159/000314311",
language = "English",
volume = "62",
pages = "61--71",
journal = "Neuropsychobiology",
issn = "0302-282X",
publisher = "S. Karger AG",
number = "1",

}

RIS

TY - JOUR

T1 - Pharmacogenetics of lithium long-term treatment

T2 - focus on initiation and adaptation mechanisms

AU - Serretti, Alessandro

AU - Drago, Antonio

N1 - Copyright 2010 S. Karger AG, Basel.

PY - 2010

Y1 - 2010

N2 - Bipolar disorder is a common disease with a high impact in terms of personal suffering and socioeconomic burden. The disentanglement of the molecular deregulations that cause this disorder is pivotal to the understanding of its etiology. This will hopefully cast the engineering of new and more favorable treatments. New insights in the molecular aspects of bipolar disorder may be brought by the understanding of the pharmacodynamics of lithium, the first-line treatment for this disease. The mechanisms by which lithium exerts its activity in the central nervous system are not fully clarified: it is hypothesized that lithium may drive acute molecular events whose activation over time triggers long-lasting modifications in critical neuronal nets. These events are associated with long-lasting changes in the expression profile of genes in neurons that are embedded in these crucial nets. The molecular events that are acutely and chronically triggered by lithium will be reviewed here and matched with the evidence that arises from the pharmacogenetics investigations. Moreover, the pharmacogenetics reports that are not strictly associated with the mechanisms that are thought to be acutely and chronically elicited by lithium will be included in the final part of the paper.

AB - Bipolar disorder is a common disease with a high impact in terms of personal suffering and socioeconomic burden. The disentanglement of the molecular deregulations that cause this disorder is pivotal to the understanding of its etiology. This will hopefully cast the engineering of new and more favorable treatments. New insights in the molecular aspects of bipolar disorder may be brought by the understanding of the pharmacodynamics of lithium, the first-line treatment for this disease. The mechanisms by which lithium exerts its activity in the central nervous system are not fully clarified: it is hypothesized that lithium may drive acute molecular events whose activation over time triggers long-lasting modifications in critical neuronal nets. These events are associated with long-lasting changes in the expression profile of genes in neurons that are embedded in these crucial nets. The molecular events that are acutely and chronically triggered by lithium will be reviewed here and matched with the evidence that arises from the pharmacogenetics investigations. Moreover, the pharmacogenetics reports that are not strictly associated with the mechanisms that are thought to be acutely and chronically elicited by lithium will be included in the final part of the paper.

KW - Animals

KW - Antimanic Agents

KW - Bipolar Disorder

KW - Humans

KW - Lithium Compounds

KW - Time Factors

U2 - 10.1159/000314311

DO - 10.1159/000314311

M3 - Journal article

C2 - 20453536

VL - 62

SP - 61

EP - 71

JO - Neuropsychobiology

JF - Neuropsychobiology

SN - 0302-282X

IS - 1

ER -