Pharmacogenetics of antidepressant response

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Pharmacogenetics of antidepressant response. / Porcelli, Stefano; Drago, Antonio; Fabbri, Chiara; Gibiino, Sara; Calati, Raffaella; Serretti, Alessandro.

I: Journal of Psychiatry and Neuroscience, Bind 36, Nr. 2, 03.2011, s. 87-113.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Porcelli, S, Drago, A, Fabbri, C, Gibiino, S, Calati, R & Serretti, A 2011, 'Pharmacogenetics of antidepressant response', Journal of Psychiatry and Neuroscience, bind 36, nr. 2, s. 87-113. https://doi.org/10.1503/jpn.100059

APA

Porcelli, S., Drago, A., Fabbri, C., Gibiino, S., Calati, R., & Serretti, A. (2011). Pharmacogenetics of antidepressant response. Journal of Psychiatry and Neuroscience, 36(2), 87-113. https://doi.org/10.1503/jpn.100059

CBE

Porcelli S, Drago A, Fabbri C, Gibiino S, Calati R, Serretti A. 2011. Pharmacogenetics of antidepressant response. Journal of Psychiatry and Neuroscience. 36(2):87-113. https://doi.org/10.1503/jpn.100059

MLA

Porcelli, Stefano o.a.. "Pharmacogenetics of antidepressant response". Journal of Psychiatry and Neuroscience. 2011, 36(2). 87-113. https://doi.org/10.1503/jpn.100059

Vancouver

Porcelli S, Drago A, Fabbri C, Gibiino S, Calati R, Serretti A. Pharmacogenetics of antidepressant response. Journal of Psychiatry and Neuroscience. 2011 mar.;36(2):87-113. https://doi.org/10.1503/jpn.100059

Author

Porcelli, Stefano ; Drago, Antonio ; Fabbri, Chiara ; Gibiino, Sara ; Calati, Raffaella ; Serretti, Alessandro. / Pharmacogenetics of antidepressant response. I: Journal of Psychiatry and Neuroscience. 2011 ; Bind 36, Nr. 2. s. 87-113.

Bibtex

@article{e94d25efc6ed4faeb151eff30a732ace,
title = "Pharmacogenetics of antidepressant response",
abstract = "Personalized medicine - the adaptation of therapies based on an individual's genetic and molecular profile - is one of the most promising aspects of modern medicine. The identification of the relation between genotype and drug response, including both the therapeutic effect and side effect profile, is expected to deeply affect medical practice. In this paper, we review the current knowledge about the genes related to antidepressant treatment response and provide methodologic proposals for future studies. We have mainly focused on genes associated with pharmacodynamics, for which a list of promising genes has been identified despite some inconsistency across studies. We have also synthesized the main results for pharmacokinetic genes, although so far they seem less relevant than those for pharmaco dynamic genes. We discuss possible reasons for these inconsistent findings and propose new study designs.",
keywords = "Antidepressive Agents, Depressive Disorder, Genotype, Humans, Pharmacogenetics, Precision Medicine",
author = "Stefano Porcelli and Antonio Drago and Chiara Fabbri and Sara Gibiino and Raffaella Calati and Alessandro Serretti",
year = "2011",
month = mar,
doi = "10.1503/jpn.100059",
language = "English",
volume = "36",
pages = "87--113",
journal = "Journal of Psychiatry and Neuroscience",
issn = "1180-4882",
publisher = "Canadian Medical Association",
number = "2",

}

RIS

TY - JOUR

T1 - Pharmacogenetics of antidepressant response

AU - Porcelli, Stefano

AU - Drago, Antonio

AU - Fabbri, Chiara

AU - Gibiino, Sara

AU - Calati, Raffaella

AU - Serretti, Alessandro

PY - 2011/3

Y1 - 2011/3

N2 - Personalized medicine - the adaptation of therapies based on an individual's genetic and molecular profile - is one of the most promising aspects of modern medicine. The identification of the relation between genotype and drug response, including both the therapeutic effect and side effect profile, is expected to deeply affect medical practice. In this paper, we review the current knowledge about the genes related to antidepressant treatment response and provide methodologic proposals for future studies. We have mainly focused on genes associated with pharmacodynamics, for which a list of promising genes has been identified despite some inconsistency across studies. We have also synthesized the main results for pharmacokinetic genes, although so far they seem less relevant than those for pharmaco dynamic genes. We discuss possible reasons for these inconsistent findings and propose new study designs.

AB - Personalized medicine - the adaptation of therapies based on an individual's genetic and molecular profile - is one of the most promising aspects of modern medicine. The identification of the relation between genotype and drug response, including both the therapeutic effect and side effect profile, is expected to deeply affect medical practice. In this paper, we review the current knowledge about the genes related to antidepressant treatment response and provide methodologic proposals for future studies. We have mainly focused on genes associated with pharmacodynamics, for which a list of promising genes has been identified despite some inconsistency across studies. We have also synthesized the main results for pharmacokinetic genes, although so far they seem less relevant than those for pharmaco dynamic genes. We discuss possible reasons for these inconsistent findings and propose new study designs.

KW - Antidepressive Agents

KW - Depressive Disorder

KW - Genotype

KW - Humans

KW - Pharmacogenetics

KW - Precision Medicine

U2 - 10.1503/jpn.100059

DO - 10.1503/jpn.100059

M3 - Journal article

C2 - 21172166

VL - 36

SP - 87

EP - 113

JO - Journal of Psychiatry and Neuroscience

JF - Journal of Psychiatry and Neuroscience

SN - 1180-4882

IS - 2

ER -