Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders

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Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders. / Pae, Chi-Un; Drago, Antonio; Forlani, Martina; Patkar, Ashwin A; Serretti, Alessandro.

I: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Bind 153B, Nr. 2, 05.03.2010, s. 680-3.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Pae, C-U, Drago, A, Forlani, M, Patkar, AA & Serretti, A 2010, 'Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, bind 153B, nr. 2, s. 680-3. https://doi.org/10.1002/ajmg.b.31009

APA

Pae, C-U., Drago, A., Forlani, M., Patkar, A. A., & Serretti, A. (2010). Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 153B(2), 680-3. https://doi.org/10.1002/ajmg.b.31009

CBE

Pae C-U, Drago A, Forlani M, Patkar AA, Serretti A. 2010. Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 153B(2):680-3. https://doi.org/10.1002/ajmg.b.31009

MLA

Pae, Chi-Un o.a.. "Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders". American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2010, 153B(2). 680-3. https://doi.org/10.1002/ajmg.b.31009

Vancouver

Pae C-U, Drago A, Forlani M, Patkar AA, Serretti A. Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2010 mar. 5;153B(2):680-3. https://doi.org/10.1002/ajmg.b.31009

Author

Pae, Chi-Un ; Drago, Antonio ; Forlani, Martina ; Patkar, Ashwin A ; Serretti, Alessandro. / Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders. I: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2010 ; Bind 153B, Nr. 2. s. 680-3.

Bibtex

@article{900a446eca9a403b87d4fb6a23d24c3e,
title = "Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders",
abstract = "Epistasis, the interaction between genes, is a topic of current interest in molecular and quantitative genetics. We have further studied a previously investigated sample of 187 major depressive disorder (MDD) patients, 171 bipolar disorder (BD) patients, and 288 controls, and tried to analyze the interaction between a set of variations of independent genes: the trace amine receptor 6 (rs4305745, rs8192625, rs7452939, rs6903874, and rs6937506) and the heat shock protein 70 (rs562047, rs1061581, rs2227956). The multifactor dimensionality reduction (MDR) method was applied and the covariates associated with diagnosis were also controlled. A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. The level of statistical significance (P < 0.001) and the testing balancing accuracy over 0.62 suggest a cautious optimism toward this result, although the possibility of false positivity warrants further analyses in independent samples.",
keywords = "Alleles, Case-Control Studies, Cell Cycle Proteins, Depressive Disorder, Major, Epistasis, Genetic, Genetic Variation, HSP70 Heat-Shock Proteins, Heterozygote, Homozygote, Humans, Models, Genetic, Mood Disorders, Nuclear Proteins, Reproducibility of Results",
author = "Chi-Un Pae and Antonio Drago and Martina Forlani and Patkar, {Ashwin A} and Alessandro Serretti",
note = "(c) 2009 Wiley-Liss, Inc.",
year = "2010",
month = mar,
day = "5",
doi = "10.1002/ajmg.b.31009",
language = "English",
volume = "153B",
pages = "680--3",
journal = "American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "JohnWiley & Sons, Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders

AU - Pae, Chi-Un

AU - Drago, Antonio

AU - Forlani, Martina

AU - Patkar, Ashwin A

AU - Serretti, Alessandro

N1 - (c) 2009 Wiley-Liss, Inc.

PY - 2010/3/5

Y1 - 2010/3/5

N2 - Epistasis, the interaction between genes, is a topic of current interest in molecular and quantitative genetics. We have further studied a previously investigated sample of 187 major depressive disorder (MDD) patients, 171 bipolar disorder (BD) patients, and 288 controls, and tried to analyze the interaction between a set of variations of independent genes: the trace amine receptor 6 (rs4305745, rs8192625, rs7452939, rs6903874, and rs6937506) and the heat shock protein 70 (rs562047, rs1061581, rs2227956). The multifactor dimensionality reduction (MDR) method was applied and the covariates associated with diagnosis were also controlled. A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. The level of statistical significance (P < 0.001) and the testing balancing accuracy over 0.62 suggest a cautious optimism toward this result, although the possibility of false positivity warrants further analyses in independent samples.

AB - Epistasis, the interaction between genes, is a topic of current interest in molecular and quantitative genetics. We have further studied a previously investigated sample of 187 major depressive disorder (MDD) patients, 171 bipolar disorder (BD) patients, and 288 controls, and tried to analyze the interaction between a set of variations of independent genes: the trace amine receptor 6 (rs4305745, rs8192625, rs7452939, rs6903874, and rs6937506) and the heat shock protein 70 (rs562047, rs1061581, rs2227956). The multifactor dimensionality reduction (MDR) method was applied and the covariates associated with diagnosis were also controlled. A significant predictive value of specific interactions between genotypes located in the investigated genes was found. We then report preliminary evidence that the epistasis between trace amine receptor 6 and heat shock protein 70 variations may compose a risk profile for major mood disorders. The level of statistical significance (P < 0.001) and the testing balancing accuracy over 0.62 suggest a cautious optimism toward this result, although the possibility of false positivity warrants further analyses in independent samples.

KW - Alleles

KW - Case-Control Studies

KW - Cell Cycle Proteins

KW - Depressive Disorder, Major

KW - Epistasis, Genetic

KW - Genetic Variation

KW - HSP70 Heat-Shock Proteins

KW - Heterozygote

KW - Homozygote

KW - Humans

KW - Models, Genetic

KW - Mood Disorders

KW - Nuclear Proteins

KW - Reproducibility of Results

U2 - 10.1002/ajmg.b.31009

DO - 10.1002/ajmg.b.31009

M3 - Journal article

C2 - 19582769

VL - 153B

SP - 680

EP - 683

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 2

ER -