Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis

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Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis. / Cocchi, Enrico; Drago, Antonio; Serretti, Alessandro.

I: Molecular Neurobiology, Bind 53, Nr. 3, 04.2016, s. 2065-81.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Cocchi, E, Drago, A & Serretti, A 2016, 'Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis', Molecular Neurobiology, bind 53, nr. 3, s. 2065-81. https://doi.org/10.1007/s12035-015-9174-6

APA

Cocchi, E., Drago, A., & Serretti, A. (2016). Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis. Molecular Neurobiology, 53(3), 2065-81. https://doi.org/10.1007/s12035-015-9174-6

CBE

Cocchi E, Drago A, Serretti A. 2016. Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis. Molecular Neurobiology. 53(3):2065-81. https://doi.org/10.1007/s12035-015-9174-6

MLA

Cocchi, Enrico, Antonio Drago og Alessandro Serretti. "Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis". Molecular Neurobiology. 2016, 53(3). 2065-81. https://doi.org/10.1007/s12035-015-9174-6

Vancouver

Cocchi E, Drago A, Serretti A. Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis. Molecular Neurobiology. 2016 apr.;53(3):2065-81. https://doi.org/10.1007/s12035-015-9174-6

Author

Cocchi, Enrico ; Drago, Antonio ; Serretti, Alessandro. / Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis. I: Molecular Neurobiology. 2016 ; Bind 53, Nr. 3. s. 2065-81.

Bibtex

@article{60ca7aa4f4744d1f99389e06fa8a1ac4,
title = "Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis",
abstract = "Pruning in neurons has been suggested to be strongly involved in Schizophrenia's (SKZ) etiopathogenesis in recent biological, imaging, and genetic studies. We investigated the impact of protein-coding genes known to be involved in pruning, collected by a systematic literature research, in shaping the risk for SKZ in a case-control sample of 9,490 subjects (Psychiatric Genomics Consortium). Moreover, their modifications through evolution (humans, chimpanzees, and rats) and subcellular localization (as indicative of their biological function) were also investigated. We also performed a biological pathways (Gene Ontology) analysis. Genetics analyses found four genes (DLG1, NOS1, THBS4, and FADS1) and 17 pathways strongly involved in pruning and SKZ in previous literature findings to be significantly associated with the sample under analysis. The analysis of the subcellular localization found that secreted genes, and so regulatory ones, are the least conserved through evolution and also the most associated with SKZ. Their cell line and regional brain expression analysis found that their areas of primary expression are neuropil and the hippocampus, respectively. At the best of our knowledge, for the first time, we were able to describe the SKZ neurodevelopmental hypothesis starting from a single biological process. We can also hypothesize how alterations in pruning fine regulation and orchestration, strongly related with the evolutionary newest (and so more sensitive) secreted proteins, may be of particular relevance in the hippocampus. This early alteration may lead to a mis-structuration of neural connectivity, resulting in the different brain alteration that characterizes SKZ patients.",
author = "Enrico Cocchi and Antonio Drago and Alessandro Serretti",
year = "2016",
month = apr,
doi = "10.1007/s12035-015-9174-6",
language = "English",
volume = "53",
pages = "2065--81",
journal = "Molecular Neurobiology",
issn = "0893-7648",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis

AU - Cocchi, Enrico

AU - Drago, Antonio

AU - Serretti, Alessandro

PY - 2016/4

Y1 - 2016/4

N2 - Pruning in neurons has been suggested to be strongly involved in Schizophrenia's (SKZ) etiopathogenesis in recent biological, imaging, and genetic studies. We investigated the impact of protein-coding genes known to be involved in pruning, collected by a systematic literature research, in shaping the risk for SKZ in a case-control sample of 9,490 subjects (Psychiatric Genomics Consortium). Moreover, their modifications through evolution (humans, chimpanzees, and rats) and subcellular localization (as indicative of their biological function) were also investigated. We also performed a biological pathways (Gene Ontology) analysis. Genetics analyses found four genes (DLG1, NOS1, THBS4, and FADS1) and 17 pathways strongly involved in pruning and SKZ in previous literature findings to be significantly associated with the sample under analysis. The analysis of the subcellular localization found that secreted genes, and so regulatory ones, are the least conserved through evolution and also the most associated with SKZ. Their cell line and regional brain expression analysis found that their areas of primary expression are neuropil and the hippocampus, respectively. At the best of our knowledge, for the first time, we were able to describe the SKZ neurodevelopmental hypothesis starting from a single biological process. We can also hypothesize how alterations in pruning fine regulation and orchestration, strongly related with the evolutionary newest (and so more sensitive) secreted proteins, may be of particular relevance in the hippocampus. This early alteration may lead to a mis-structuration of neural connectivity, resulting in the different brain alteration that characterizes SKZ patients.

AB - Pruning in neurons has been suggested to be strongly involved in Schizophrenia's (SKZ) etiopathogenesis in recent biological, imaging, and genetic studies. We investigated the impact of protein-coding genes known to be involved in pruning, collected by a systematic literature research, in shaping the risk for SKZ in a case-control sample of 9,490 subjects (Psychiatric Genomics Consortium). Moreover, their modifications through evolution (humans, chimpanzees, and rats) and subcellular localization (as indicative of their biological function) were also investigated. We also performed a biological pathways (Gene Ontology) analysis. Genetics analyses found four genes (DLG1, NOS1, THBS4, and FADS1) and 17 pathways strongly involved in pruning and SKZ in previous literature findings to be significantly associated with the sample under analysis. The analysis of the subcellular localization found that secreted genes, and so regulatory ones, are the least conserved through evolution and also the most associated with SKZ. Their cell line and regional brain expression analysis found that their areas of primary expression are neuropil and the hippocampus, respectively. At the best of our knowledge, for the first time, we were able to describe the SKZ neurodevelopmental hypothesis starting from a single biological process. We can also hypothesize how alterations in pruning fine regulation and orchestration, strongly related with the evolutionary newest (and so more sensitive) secreted proteins, may be of particular relevance in the hippocampus. This early alteration may lead to a mis-structuration of neural connectivity, resulting in the different brain alteration that characterizes SKZ patients.

U2 - 10.1007/s12035-015-9174-6

DO - 10.1007/s12035-015-9174-6

M3 - Journal article

C2 - 25902861

VL - 53

SP - 2065

EP - 2081

JO - Molecular Neurobiology

JF - Molecular Neurobiology

SN - 0893-7648

IS - 3

ER -