Antonio Drago

Genetic determinants of psychic resilience after a diagnosis of cancer

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Comorbidity between cancer and psychiatric disorders including adjustment disorder, depressive disorders or angst can seriously influence the prognosis and the quality of life of patients. The identification of the psychological and biological profile of patients at risk for such comorbidity is not yet available. Classical candidate genes such as the BDNF, the 5-HTLPR and genes whose products are involved in inflammatory events have received some attention, but results are inconclusive.the present review the association between cancer and psychiatric disorders is reviewed, a focus on the investigation of the Gene X Environment and the epigenetic control over the activation of the HPA axis is proposed as a tool to refine the definition of the biologic profile at risk for comorbidity between psychiatry and cancer.
OriginalsprogEngelsk
TidsskriftIntegrative Cancer Science and Therapeutics
Vol/bind3
Nummer4
ISSN2056-4546
StatusUdgivet - 25 jul. 2016

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