Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment

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Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment. / Pae, Chi-Un; Drago, Antonio; Patkar, Ashwin A; Jun, Tae-Youn; Serretti, Alessandro.

I: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Bind 19, Nr. 11, 11.2009, s. 806-11.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Pae, C-U, Drago, A, Patkar, AA, Jun, T-Y & Serretti, A 2009, 'Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment', European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, bind 19, nr. 11, s. 806-11. https://doi.org/10.1016/j.euroneuro.2009.07.001

APA

Pae, C-U., Drago, A., Patkar, A. A., Jun, T-Y., & Serretti, A. (2009). Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19(11), 806-11. https://doi.org/10.1016/j.euroneuro.2009.07.001

CBE

Pae C-U, Drago A, Patkar AA, Jun T-Y, Serretti A. 2009. Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 19(11):806-11. https://doi.org/10.1016/j.euroneuro.2009.07.001

MLA

Pae, Chi-Un o.a.. "Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment". European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2009, 19(11). 806-11. https://doi.org/10.1016/j.euroneuro.2009.07.001

Vancouver

Pae C-U, Drago A, Patkar AA, Jun T-Y, Serretti A. Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2009 nov.;19(11):806-11. https://doi.org/10.1016/j.euroneuro.2009.07.001

Author

Pae, Chi-Un ; Drago, Antonio ; Patkar, Ashwin A ; Jun, Tae-Youn ; Serretti, Alessandro. / Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment. I: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2009 ; Bind 19, Nr. 11. s. 806-11.

Bibtex

@article{d38a142838ef42299a49d5aa9862ede8,
title = "Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment",
abstract = "Suggestive associations have been reported between trace amines and heat shock proteins, and a disrupted pathophysiology that enhances the risk of psychosis and that modifies responses to antipsychotic treatments. Our group previously reported genetic studies on TAAR6 and HSP-70 separately in patients with schizophrenia. In the current study, we investigated possible epistasis between the same set of variations in a sample of 281 patients diagnosed with schizophrenia and 288 healthy controls. We applied the generalized multifactor dimensionality reduction (MDR) method and controlled covariates significantly associated with both diagnosis and treatment efficacy. To the best of our knowledge, epistasis between the present set of variations in schizophrenia has not been tested before. We found significant associations with both the risk of disease and response to treatment. However, the insufficiently balanced accuracy of the applied tests suggests that, despite significantly different genetic variations between cases and controls, these factors have a poor predictive value. Explanations for these findings and possible future directions are also discussed.",
keywords = "Antipsychotic Agents, Cell Cycle Proteins, Epistasis, Genetic, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genotype, HSP72 Heat-Shock Proteins, Humans, Nuclear Proteins, Polymorphism, Single Nucleotide, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology",
author = "Chi-Un Pae and Antonio Drago and Patkar, {Ashwin A} and Tae-Youn Jun and Alessandro Serretti",
year = "2009",
month = nov,
doi = "10.1016/j.euroneuro.2009.07.001",
language = "English",
volume = "19",
pages = "806--11",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier BV",
number = "11",

}

RIS

TY - JOUR

T1 - Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment

AU - Pae, Chi-Un

AU - Drago, Antonio

AU - Patkar, Ashwin A

AU - Jun, Tae-Youn

AU - Serretti, Alessandro

PY - 2009/11

Y1 - 2009/11

N2 - Suggestive associations have been reported between trace amines and heat shock proteins, and a disrupted pathophysiology that enhances the risk of psychosis and that modifies responses to antipsychotic treatments. Our group previously reported genetic studies on TAAR6 and HSP-70 separately in patients with schizophrenia. In the current study, we investigated possible epistasis between the same set of variations in a sample of 281 patients diagnosed with schizophrenia and 288 healthy controls. We applied the generalized multifactor dimensionality reduction (MDR) method and controlled covariates significantly associated with both diagnosis and treatment efficacy. To the best of our knowledge, epistasis between the present set of variations in schizophrenia has not been tested before. We found significant associations with both the risk of disease and response to treatment. However, the insufficiently balanced accuracy of the applied tests suggests that, despite significantly different genetic variations between cases and controls, these factors have a poor predictive value. Explanations for these findings and possible future directions are also discussed.

AB - Suggestive associations have been reported between trace amines and heat shock proteins, and a disrupted pathophysiology that enhances the risk of psychosis and that modifies responses to antipsychotic treatments. Our group previously reported genetic studies on TAAR6 and HSP-70 separately in patients with schizophrenia. In the current study, we investigated possible epistasis between the same set of variations in a sample of 281 patients diagnosed with schizophrenia and 288 healthy controls. We applied the generalized multifactor dimensionality reduction (MDR) method and controlled covariates significantly associated with both diagnosis and treatment efficacy. To the best of our knowledge, epistasis between the present set of variations in schizophrenia has not been tested before. We found significant associations with both the risk of disease and response to treatment. However, the insufficiently balanced accuracy of the applied tests suggests that, despite significantly different genetic variations between cases and controls, these factors have a poor predictive value. Explanations for these findings and possible future directions are also discussed.

KW - Antipsychotic Agents

KW - Cell Cycle Proteins

KW - Epistasis, Genetic

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Genotype

KW - HSP72 Heat-Shock Proteins

KW - Humans

KW - Nuclear Proteins

KW - Polymorphism, Single Nucleotide

KW - Psychiatric Status Rating Scales

KW - Schizophrenia

KW - Schizophrenic Psychology

U2 - 10.1016/j.euroneuro.2009.07.001

DO - 10.1016/j.euroneuro.2009.07.001

M3 - Journal article

C2 - 19643584

VL - 19

SP - 806

EP - 811

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 11

ER -