Antonio Drago

DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Chi-Un Pae
  • ,
  • Antonio Drago
  • Jung-Jin Kim
  • ,
  • Ashwin A Patkar
  • ,
  • Tae-Youn Jun
  • ,
  • Chul Lee
  • ,
  • Laura Mandelli
  • ,
  • Diana De Ronchi
  • ,
  • In-Ho Paik
  • ,
  • Alessandro Serretti

Dysbindin gene (DTNBP1) has been associated with schizophrenia, but literature findings are inconsistent, and further analyses are required. This study is aimed to investigate if a set of DTNBP1 variations might influence clinic psychotic phenotype or treatment response in a sample of 240 Korean schizophrenic in-patients. Four variants have been selected (rs3213207; rs1011313; rs16876759; rs2619522) on the basis of previous findings of association with schizophrenia, bipolar disorder and antidepressant response. Single marker analysis gave marginal results. Haplotype analysis identified a significant association between A-A (rs3213207(A/G), rs1011313(A/G)) haplotype and lower PANSS total and positive scores at baseline (p=0.01; 0.02) and at discharge (p=0.008; 0.005). Covariate analysis revealed a more stable significant association between A-A haplotype and baseline scores. These results suggest a protective effect of A-A haplotype on psychotic positive symptoms at baseline.

OriginalsprogEngelsk
TidsskriftNeuroscience Letters
Vol/bind440
Nummer2
Sider (fra-til)150-4
Antal sider5
ISSN0304-3940
DOI
StatusUdgivet - 1 aug. 2008

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