DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy

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DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy. / Arias, Bárbara; Fabbri, Chiara; Serretti, Alessandro; Drago, Antonio; Mitjans, Marina; Gastó, Cristóbal; Catalán, Rosa; Fañanás, Lourdes.

I: Journal of Affective Disorders, Bind 168, 2014, s. 91-7.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Arias, B, Fabbri, C, Serretti, A, Drago, A, Mitjans, M, Gastó, C, Catalán, R & Fañanás, L 2014, 'DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy', Journal of Affective Disorders, bind 168, s. 91-7. https://doi.org/10.1016/j.jad.2014.06.048

APA

Arias, B., Fabbri, C., Serretti, A., Drago, A., Mitjans, M., Gastó, C., Catalán, R., & Fañanás, L. (2014). DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy. Journal of Affective Disorders, 168, 91-7. https://doi.org/10.1016/j.jad.2014.06.048

CBE

Arias B, Fabbri C, Serretti A, Drago A, Mitjans M, Gastó C, Catalán R, Fañanás L. 2014. DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy. Journal of Affective Disorders. 168:91-7. https://doi.org/10.1016/j.jad.2014.06.048

MLA

Vancouver

Arias B, Fabbri C, Serretti A, Drago A, Mitjans M, Gastó C o.a. DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy. Journal of Affective Disorders. 2014;168:91-7. https://doi.org/10.1016/j.jad.2014.06.048

Author

Arias, Bárbara ; Fabbri, Chiara ; Serretti, Alessandro ; Drago, Antonio ; Mitjans, Marina ; Gastó, Cristóbal ; Catalán, Rosa ; Fañanás, Lourdes. / DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy. I: Journal of Affective Disorders. 2014 ; Bind 168. s. 91-7.

Bibtex

@article{cebe4ca6cac747e7b2a23fc1e223a34c,
title = "DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy",
abstract = "BACKGROUND: Major depressive disorder (MDD) is a common disease with high morbidity and still unsatisfying treatment response. Both MDD pathogenesis and antidepressant effect are supposed to be strongly affected by genetic polymorphisms. Among promising candidate genes, distrupted in schizophrenia 1 (DISC1), translin-associated factor X (TSNAX) and D-amino acid oxidase activator (DAOA) were suggested since their regulator role in neurodevelopment, neuroplasticity and neurotransmission, and previous evidence of cross-involvement in major psychiatric diseases.METHODS: The present paper investigated the role of 13 SNPs within the reported genes in MDD susceptibility through a case-control (n=320 and n=150, respectively) study and in citalopram efficacy (n=157). Measures of citalopram efficacy were response (4th week) and remission (12th week). Pharmacogenetic findings were tested in the STAR(⁎)D genome-wide dataset (n=1892) for replication.RESULTS: Evidence of association among rs3738401 (DISC1), rs1615409 and rs766288 (TSNAX) and MDD was found (p=0.004, p=0.0019, and p=0.008, respectively). A trend of association between remission and DISC1 rs821616 and DAOA rs778294 was detected, and confirmation was found for rs778294 by repeated-measure ANOVA (p=0.0008). In the STAR(⁎)D a cluster of SNPs from 20 to 40Kbp from DISC1 findings in the original sample was associated with citalopram response, as well as rs778330 (12,325bp from rs778294).LIMITATIONS: Relatively small size of the original sample and focus on only three candidate genes.CONCLUSIONS: The present study supported a role of DISC1-TSNAX variants in MDD susceptibility. On the other hand, genetic regions around DAOA rs778294 and DISC1 rs6675281-rs1000731 may influence citalopram efficacy.",
keywords = "Adult, Analysis of Variance, Antidepressive Agents, Antidepressive Agents, Second-Generation, Case-Control Studies, Depressive Disorder, Major, Female, Humans, Male, Polymorphism, Single Nucleotide, Spain, Treatment Outcome",
author = "B{\'a}rbara Arias and Chiara Fabbri and Alessandro Serretti and Antonio Drago and Marina Mitjans and Crist{\'o}bal Gast{\'o} and Rosa Catal{\'a}n and Lourdes Fa{\~n}an{\'a}s",
note = "Copyright {\textcopyright} 2014 Elsevier B.V. All rights reserved.",
year = "2014",
doi = "10.1016/j.jad.2014.06.048",
language = "English",
volume = "168",
pages = "91--7",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy

AU - Arias, Bárbara

AU - Fabbri, Chiara

AU - Serretti, Alessandro

AU - Drago, Antonio

AU - Mitjans, Marina

AU - Gastó, Cristóbal

AU - Catalán, Rosa

AU - Fañanás, Lourdes

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Major depressive disorder (MDD) is a common disease with high morbidity and still unsatisfying treatment response. Both MDD pathogenesis and antidepressant effect are supposed to be strongly affected by genetic polymorphisms. Among promising candidate genes, distrupted in schizophrenia 1 (DISC1), translin-associated factor X (TSNAX) and D-amino acid oxidase activator (DAOA) were suggested since their regulator role in neurodevelopment, neuroplasticity and neurotransmission, and previous evidence of cross-involvement in major psychiatric diseases.METHODS: The present paper investigated the role of 13 SNPs within the reported genes in MDD susceptibility through a case-control (n=320 and n=150, respectively) study and in citalopram efficacy (n=157). Measures of citalopram efficacy were response (4th week) and remission (12th week). Pharmacogenetic findings were tested in the STAR(⁎)D genome-wide dataset (n=1892) for replication.RESULTS: Evidence of association among rs3738401 (DISC1), rs1615409 and rs766288 (TSNAX) and MDD was found (p=0.004, p=0.0019, and p=0.008, respectively). A trend of association between remission and DISC1 rs821616 and DAOA rs778294 was detected, and confirmation was found for rs778294 by repeated-measure ANOVA (p=0.0008). In the STAR(⁎)D a cluster of SNPs from 20 to 40Kbp from DISC1 findings in the original sample was associated with citalopram response, as well as rs778330 (12,325bp from rs778294).LIMITATIONS: Relatively small size of the original sample and focus on only three candidate genes.CONCLUSIONS: The present study supported a role of DISC1-TSNAX variants in MDD susceptibility. On the other hand, genetic regions around DAOA rs778294 and DISC1 rs6675281-rs1000731 may influence citalopram efficacy.

AB - BACKGROUND: Major depressive disorder (MDD) is a common disease with high morbidity and still unsatisfying treatment response. Both MDD pathogenesis and antidepressant effect are supposed to be strongly affected by genetic polymorphisms. Among promising candidate genes, distrupted in schizophrenia 1 (DISC1), translin-associated factor X (TSNAX) and D-amino acid oxidase activator (DAOA) were suggested since their regulator role in neurodevelopment, neuroplasticity and neurotransmission, and previous evidence of cross-involvement in major psychiatric diseases.METHODS: The present paper investigated the role of 13 SNPs within the reported genes in MDD susceptibility through a case-control (n=320 and n=150, respectively) study and in citalopram efficacy (n=157). Measures of citalopram efficacy were response (4th week) and remission (12th week). Pharmacogenetic findings were tested in the STAR(⁎)D genome-wide dataset (n=1892) for replication.RESULTS: Evidence of association among rs3738401 (DISC1), rs1615409 and rs766288 (TSNAX) and MDD was found (p=0.004, p=0.0019, and p=0.008, respectively). A trend of association between remission and DISC1 rs821616 and DAOA rs778294 was detected, and confirmation was found for rs778294 by repeated-measure ANOVA (p=0.0008). In the STAR(⁎)D a cluster of SNPs from 20 to 40Kbp from DISC1 findings in the original sample was associated with citalopram response, as well as rs778330 (12,325bp from rs778294).LIMITATIONS: Relatively small size of the original sample and focus on only three candidate genes.CONCLUSIONS: The present study supported a role of DISC1-TSNAX variants in MDD susceptibility. On the other hand, genetic regions around DAOA rs778294 and DISC1 rs6675281-rs1000731 may influence citalopram efficacy.

KW - Adult

KW - Analysis of Variance

KW - Antidepressive Agents

KW - Antidepressive Agents, Second-Generation

KW - Case-Control Studies

KW - Depressive Disorder, Major

KW - Female

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Spain

KW - Treatment Outcome

U2 - 10.1016/j.jad.2014.06.048

DO - 10.1016/j.jad.2014.06.048

M3 - Journal article

C2 - 25043320

VL - 168

SP - 91

EP - 97

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -