A molecular pathway analysis informs the genetic background at risk for schizophrenia

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A molecular pathway analysis informs the genetic background at risk for schizophrenia. / Crisafulli, Concetta; Drago, Antonio; Calabrò, Marco; Spina, Edoardo; Serretti, Alessandro.

I: Progress in Neuro-Psychopharmacology & Biological Psychiatry, Bind 59, 03.06.2015, s. 21-30.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Crisafulli, C, Drago, A, Calabrò, M, Spina, E & Serretti, A 2015, 'A molecular pathway analysis informs the genetic background at risk for schizophrenia', Progress in Neuro-Psychopharmacology & Biological Psychiatry, bind 59, s. 21-30. https://doi.org/10.1016/j.pnpbp.2014.12.009

APA

Crisafulli, C., Drago, A., Calabrò, M., Spina, E., & Serretti, A. (2015). A molecular pathway analysis informs the genetic background at risk for schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 59, 21-30. https://doi.org/10.1016/j.pnpbp.2014.12.009

CBE

Crisafulli C, Drago A, Calabrò M, Spina E, Serretti A. 2015. A molecular pathway analysis informs the genetic background at risk for schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 59:21-30. https://doi.org/10.1016/j.pnpbp.2014.12.009

MLA

Crisafulli, Concetta o.a.. "A molecular pathway analysis informs the genetic background at risk for schizophrenia". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2015, 59. 21-30. https://doi.org/10.1016/j.pnpbp.2014.12.009

Vancouver

Crisafulli C, Drago A, Calabrò M, Spina E, Serretti A. A molecular pathway analysis informs the genetic background at risk for schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2015 jun. 3;59:21-30. https://doi.org/10.1016/j.pnpbp.2014.12.009

Author

Crisafulli, Concetta ; Drago, Antonio ; Calabrò, Marco ; Spina, Edoardo ; Serretti, Alessandro. / A molecular pathway analysis informs the genetic background at risk for schizophrenia. I: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2015 ; Bind 59. s. 21-30.

Bibtex

@article{98338159c7ed4a66a6ed99fb17ad3ba4,
title = "A molecular pathway analysis informs the genetic background at risk for schizophrenia",
abstract = "BACKGROUND: Schizophrenia is a complex mental disorder marked by severely impaired thinking, delusional thoughts, hallucinations and poor emotional responsiveness. The biological mechanisms that lead to schizophrenia may be related to the genetic background of patients. Thus, a genetic perspective may help to unravel the molecular pathways disrupted in schizophrenia.METHODS: In the present work, we used a molecular pathway analysis to identify the molecular pathways associated with schizophrenia. We collected data of genetic loci previously associated with schizophrenia, identified the genes located in those positions and created the metabolic pathways that are related to those genes' products. These pathways were tested for enrichment (a number of SNPs associated with the phenotype significantly higher than expected by chance) in a sample of schizophrenic patients and controls (4486 and 4477, respectively).RESULTS: The molecular pathway that resulted from the identification of all the genes located in the loci previously found to be associated with schizophrenia was found to be enriched, as expected (permutated p(10(6))=9.9999e-06).We found 60 SNPs amongst 30 different genes with a strong association with schizophrenia. The genes are related to the pathways related to neurodevelopment, apoptosis, vesicle traffic, immune response and MAPK cascade.CONCLUSIONS: The pathway related to the toll-like receptor family seemed to play a central role in the modulation/connection of various pathways whose disruption leads to schizophrenia. This pathway is related to the innate immune system, further stressing the role of immunological-related events in increasing the risk to schizophrenia.",
keywords = "Databases, Factual, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Metabolic Networks and Pathways, Polymorphism, Single Nucleotide, Schizophrenia, Signal Transduction, Toll-Like Receptors",
author = "Concetta Crisafulli and Antonio Drago and Marco Calabr{\`o} and Edoardo Spina and Alessandro Serretti",
note = "Copyright {\textcopyright} 2014. Published by Elsevier Inc.",
year = "2015",
month = jun,
day = "3",
doi = "10.1016/j.pnpbp.2014.12.009",
language = "English",
volume = "59",
pages = "21--30",
journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - A molecular pathway analysis informs the genetic background at risk for schizophrenia

AU - Crisafulli, Concetta

AU - Drago, Antonio

AU - Calabrò, Marco

AU - Spina, Edoardo

AU - Serretti, Alessandro

N1 - Copyright © 2014. Published by Elsevier Inc.

PY - 2015/6/3

Y1 - 2015/6/3

N2 - BACKGROUND: Schizophrenia is a complex mental disorder marked by severely impaired thinking, delusional thoughts, hallucinations and poor emotional responsiveness. The biological mechanisms that lead to schizophrenia may be related to the genetic background of patients. Thus, a genetic perspective may help to unravel the molecular pathways disrupted in schizophrenia.METHODS: In the present work, we used a molecular pathway analysis to identify the molecular pathways associated with schizophrenia. We collected data of genetic loci previously associated with schizophrenia, identified the genes located in those positions and created the metabolic pathways that are related to those genes' products. These pathways were tested for enrichment (a number of SNPs associated with the phenotype significantly higher than expected by chance) in a sample of schizophrenic patients and controls (4486 and 4477, respectively).RESULTS: The molecular pathway that resulted from the identification of all the genes located in the loci previously found to be associated with schizophrenia was found to be enriched, as expected (permutated p(10(6))=9.9999e-06).We found 60 SNPs amongst 30 different genes with a strong association with schizophrenia. The genes are related to the pathways related to neurodevelopment, apoptosis, vesicle traffic, immune response and MAPK cascade.CONCLUSIONS: The pathway related to the toll-like receptor family seemed to play a central role in the modulation/connection of various pathways whose disruption leads to schizophrenia. This pathway is related to the innate immune system, further stressing the role of immunological-related events in increasing the risk to schizophrenia.

AB - BACKGROUND: Schizophrenia is a complex mental disorder marked by severely impaired thinking, delusional thoughts, hallucinations and poor emotional responsiveness. The biological mechanisms that lead to schizophrenia may be related to the genetic background of patients. Thus, a genetic perspective may help to unravel the molecular pathways disrupted in schizophrenia.METHODS: In the present work, we used a molecular pathway analysis to identify the molecular pathways associated with schizophrenia. We collected data of genetic loci previously associated with schizophrenia, identified the genes located in those positions and created the metabolic pathways that are related to those genes' products. These pathways were tested for enrichment (a number of SNPs associated with the phenotype significantly higher than expected by chance) in a sample of schizophrenic patients and controls (4486 and 4477, respectively).RESULTS: The molecular pathway that resulted from the identification of all the genes located in the loci previously found to be associated with schizophrenia was found to be enriched, as expected (permutated p(10(6))=9.9999e-06).We found 60 SNPs amongst 30 different genes with a strong association with schizophrenia. The genes are related to the pathways related to neurodevelopment, apoptosis, vesicle traffic, immune response and MAPK cascade.CONCLUSIONS: The pathway related to the toll-like receptor family seemed to play a central role in the modulation/connection of various pathways whose disruption leads to schizophrenia. This pathway is related to the innate immune system, further stressing the role of immunological-related events in increasing the risk to schizophrenia.

KW - Databases, Factual

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Metabolic Networks and Pathways

KW - Polymorphism, Single Nucleotide

KW - Schizophrenia

KW - Signal Transduction

KW - Toll-Like Receptors

U2 - 10.1016/j.pnpbp.2014.12.009

DO - 10.1016/j.pnpbp.2014.12.009

M3 - Journal article

C2 - 25554435

VL - 59

SP - 21

EP - 30

JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry

SN - 0278-5846

ER -