Annie Vesterby

Chronic Alcohol Abuse Leads to Low Bone Mass with No General Loss of Bone Structure or Bone Mechanical Strength

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Maiken Parm Ulhøi, Department of Forensic Medicine, University of Aarhus, Palle Juul-Jensens Boulevard 99, DK-8200, Arhus N, Denmark.
  • ,
  • Karoline Meldgaard, Department of Internal Medicine, Regional Hospital West Jutland, Gl. Landevej 61, DK-7400, Herning, Denmark.
  • ,
  • Torben Steiniche
  • Anders Odgaard, Department of Orthopaedics, Copenhagen University Hospital Gentofte, Kildegaardsvej 28, DK-2900, Hellerup, Denmark.
  • ,
  • Annie Vesterby

Chronic alcohol abuse (CAA) has deleterious effects on skeletal health. This study examined the impact of CAA on bone with regard to bone density, structure, and strength. Bone specimens from 42 individuals with CAA and 42 individuals without alcohol abuse were obtained at autopsy. Dual-energy X-ray absorptiometry (DEXA), compression testing, ashing, and bone histomorphometry were performed. Individuals with CAA had significantly lower bone mineral density (BMD) in the femoral neck and significantly lower bone volume demonstrated by thinner trabeculae, decreased extent of osteoid surfaces, and lower mean wall thickness of trabecular osteons compared to individuals without alcohol abuse. No significant difference was found for bone strength and structure.

CONCLUSION: CAA leads to low bone mass due to a decrease in bone formation but with no destruction of bone architecture nor a decrease in bone strength. It is questionable whether this per se increases fracture risk.

OriginalsprogEngelsk
TidsskriftJournal of Forensic Sciences
Vol/bind62
Nummer1
Sider (fra-til)131-136
Antal sider6
ISSN0022-1198
DOI
StatusUdgivet - jan. 2017

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