Anni Nørgaard Jeppesen

Quality of targeted temperature management and outcome of out-of-hospital cardiac arrest patients: A post hoc analysis of the TTH48 study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Chiara De Fazio, Université Libre de Bruxelles
  • ,
  • Markus B Skrifvars, University of Helsinki
  • ,
  • Eldar Søreide, Department of Biology, University of Bergen, Bergen, Norway; Sars International Centre, Uni Research, University of Bergen, Bergen, Norway.
  • ,
  • Anders M Grejs
  • Eugenio Di Bernardini, Université Libre de Bruxelles
  • ,
  • Anni Nørgaard Jeppesen
  • Christian Storm, Charité-Universitätsmedizin Berlin
  • ,
  • Jesper Kjaergaard, Université Libre de Bruxelles
  • ,
  • Timo Laitio, University of Turku
  • ,
  • Bodil Sten Rasmussen, Aalborg Universitet
  • ,
  • Marjaana Tianen, University of Helsinki
  • ,
  • Hans Kirkegaard
  • Fabio Silvio Taccone, Université Libre de Bruxelles
  • ,
  • TTH48 Investigators

BACKGROUND: No data are available on the quality of targeted temperature management (TTM) provided to out-of-hospital cardiac arrest (OHCA) patients and its association with outcome.

METHODS: Post hoc analysis of the TTH48 study (NCT01689077), which compared the effects of prolonged TTM at 33 °C for 48 h to standard 24-h TTM on neurologic outcome. Admission temperature, speed of cooling, rewarming rates, precision (i.e. temperature variability), overcooling and overshooting as post-cooling fever (i.e. >38.0 °C) were collected. A specific score, ranging from 1 to 9, was computed to define the "quality of TTM".

RESULTS: On a total of 352 patients, most had a moderate quality of TTM (n = 217; 62% - score 4-6), while 80 (23%) patients had a low quality of TTM (score 1-3) and only 52 (16%) a high quality of TTM (score 7-9). The proportion of patients with unfavorable neurological outcome (UO; Cerebral Performance Category of 3-5 at 6 months) was similar between the different quality of TTM groups (p = 0.90). Although a shorter time from arrest to target temperature and a lower proportion of time outside the target ranges in the TTM 48-h than in the TTM 24-h group, quality of TTM was similar between groups. Also, the proportion of patients with UO was similar between the different quality of TTM groups when TTM 48-h and TTM 24-h were compared.

CONCLUSIONS: In this study, high quality of TTM was provided to a small proportion of patients. However, quality of TTM was not associated with patients' outcome.

Sider (fra-til)85-92
Antal sider8
StatusUdgivet - aug. 2021

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