Annette de Thurah

Efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases: A systematic literature review for the 2019 update of EULAR recommendations

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

DOI

  • Christien Rondaan, University of Groningen
  • ,
  • Victoria Furer, Tel Aviv Sourasky Medical Center, Tel Aviv University
  • ,
  • Marloes W. Heijstek, Utrecht University
  • ,
  • Nancy Agmon-Levin, Tel Aviv University, Chaim Sheba Medical Center Israel
  • ,
  • Marc Bijl, Martini Ziekenhuis
  • ,
  • Ferdinand C. Breedveld, Department of Human Genetics, Leiden University Medical Center (LUMC).
  • ,
  • Raffaele D'Amelio, Sapienza University of Rome
  • ,
  • Maxime Dougados, Universite Paris 5, Clinical Epidemiology and Biostatistics
  • ,
  • Meliha C. Kapetanovic, Lund University
  • ,
  • Jacob M. Van Laar, Utrecht University
  • ,
  • Annette Ladefoged De Thurah
  • Robert Landewé, University of Amsterdam, Zuyderland Medical Centre
  • ,
  • Anna Molto, Universite Paris 5
  • ,
  • Ulf Müller-Ladner, Institute of Inorganic and Analytical Chemistry
  • ,
  • Karen Schreiber, Guy's and St Thomas' NHS Foundation Trust, King Christian x'S Hospital for Rheumatic Diseases in Gråsten
  • ,
  • Leo Smolar, Patient Research Partner
  • ,
  • Jim Walker, Patient Research Partner
  • ,
  • Klaus Warnatz, University of Freiburg
  • ,
  • Nico M. Wulffraat, Utrecht University
  • ,
  • Sander Van Assen, Treant Care Group
  • ,
  • Ori Elkayam, Tel Aviv Sourasky Medical Center, Tel Aviv University

Aim To present a systematic literature review (SLR) on efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD), aiming to provide a basis for updating the EULAR evidence-based recommendations. Methods An SLR was performed according to the standard operating procedures for EULAR-endorsed recommendations. Outcome was determined by efficacy, immunogenicity and safety of vaccination in adult patients with AIIRD, including those receiving immunomodulating therapy. Furthermore, a search was performed on the effect of vaccinating household members of patients with AIIRD on the occurrence of vaccine-preventable infections in patients and their household members (including newborns). The literature search was performed using Medline, Embase and the Cochrane Library (October 2009 to August 2018). Results While most investigated vaccines were efficacious and/or immunogenic in patients with AIIRD, some were less efficacious than in healthy control subjects, and/or in patients receiving immunosuppressive agents. Adverse events of vaccination were generally mild and the rates were comparable to those in healthy persons. Vaccination did not seem to lead to an increase in activity of the underlying AIIRD, but insufficient power of most studies precluded arriving at definite conclusions. The number of studies investigating clinical efficacy of vaccination is still limited. No studies on the effect of vaccinating household members of patients with AIIRD were retrieved. Conclusion Evidence on efficacy, immunogenicity and safety of vaccination in patients with AIIRD was systematically reviewed to provide a basis for updated recommendations.

OriginalsprogEngelsk
Artikelnummere001035
TidsskriftRMD Open
Vol/bind5
Nummer2
Antal sider27
DOI
StatusUdgivet - 1 sep. 2019

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