Institut for Biomedicin

Annemarie Brüel

Pantoprazole, a proton pump inhibitor, does not prevent botulinum toxin induced disuse osteopenia in mice

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Pantoprazole, a proton pump inhibitor, does not prevent botulinum toxin induced disuse osteopenia in mice. / Vegger, J B; Brüel, A; Thomsen, J S.

I: Journal of Musculoskeletal and Neuronal Interactions, Bind 17, Nr. 3, 01.09.2017, s. 162-175.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Vegger, JB, Brüel, A & Thomsen, JS 2017, 'Pantoprazole, a proton pump inhibitor, does not prevent botulinum toxin induced disuse osteopenia in mice', Journal of Musculoskeletal and Neuronal Interactions, bind 17, nr. 3, s. 162-175.

APA

Vegger, J. B., Brüel, A., & Thomsen, J. S. (2017). Pantoprazole, a proton pump inhibitor, does not prevent botulinum toxin induced disuse osteopenia in mice. Journal of Musculoskeletal and Neuronal Interactions, 17(3), 162-175.

CBE

Vegger JB, Brüel A, Thomsen JS. 2017. Pantoprazole, a proton pump inhibitor, does not prevent botulinum toxin induced disuse osteopenia in mice. Journal of Musculoskeletal and Neuronal Interactions. 17(3):162-175.

MLA

Vegger, J B, A Brüel, og J S Thomsen. "Pantoprazole, a proton pump inhibitor, does not prevent botulinum toxin induced disuse osteopenia in mice". Journal of Musculoskeletal and Neuronal Interactions. 2017, 17(3). 162-175.

Vancouver

Vegger JB, Brüel A, Thomsen JS. Pantoprazole, a proton pump inhibitor, does not prevent botulinum toxin induced disuse osteopenia in mice. Journal of Musculoskeletal and Neuronal Interactions. 2017 sep 1;17(3):162-175.

Author

Vegger, J B ; Brüel, A ; Thomsen, J S. / Pantoprazole, a proton pump inhibitor, does not prevent botulinum toxin induced disuse osteopenia in mice. I: Journal of Musculoskeletal and Neuronal Interactions. 2017 ; Bind 17, Nr. 3. s. 162-175.

Bibtex

@article{1836fd1b47df45dfb6eb6d478cefce58,
title = "Pantoprazole, a proton pump inhibitor, does not prevent botulinum toxin induced disuse osteopenia in mice",
abstract = "OBJECTIVES: Pantoprazole is a proton pump inhibitor that has been shown to inhibit bone resorption. The aim of the study was to investigate whether pantoprazole can prevent development of botulinum toxin (BTX)-induced disuse osteopenia in mice.METHODS: Forty-eight 16-week-old female C57BL/6J mice were randomized into 4 groups (n=12): Base, Ctrl, BTX, and BTX+Pan. The Base group was euthanized at study start. The BTX and BTX+Pan groups were immobilized by injections with BTX in one hind limb. The BTX+Pan group was injected i.p. daily with 100 mg pantoprazole per kg bodyweight. The mice were euthanized after 3 weeks of treatment. The skeletal status was investigated by DEXA, µCT, mechanical testing, dynamic bone histomorphometry, and RT-qPCR. The bone sites investigated were tibia, femur, L5 vertebra, and humerus.RESULTS: Injections of BTX induced a pronounced and significant loss of bone density, microstructure, and strength in the immobilized hind limb. Furthermore, the localized intramuscular injections of BTX lead to a slight loss of bone and bone strength at the L5 vertebra and humerus. Treatment with pantoprazole did not have any bone protective or deleterious effects.CONCLUSION: Pantoprazole was unable to prevent the development of BTX induced disuse osteopenia in skeletally mature female C57BL/6J mice.",
keywords = "Journal Article",
author = "Vegger, {J B} and A Br{\"u}el and Thomsen, {J S}",
year = "2017",
month = sep,
day = "1",
language = "English",
volume = "17",
pages = "162--175",
journal = "Journal of Musculoskeletal and Neuronal Interactions",
issn = "1108-7161",
publisher = "The/International Society of Musculoskeletal and Neuronal Interactions",
number = "3",

}

RIS

TY - JOUR

T1 - Pantoprazole, a proton pump inhibitor, does not prevent botulinum toxin induced disuse osteopenia in mice

AU - Vegger, J B

AU - Brüel, A

AU - Thomsen, J S

PY - 2017/9/1

Y1 - 2017/9/1

N2 - OBJECTIVES: Pantoprazole is a proton pump inhibitor that has been shown to inhibit bone resorption. The aim of the study was to investigate whether pantoprazole can prevent development of botulinum toxin (BTX)-induced disuse osteopenia in mice.METHODS: Forty-eight 16-week-old female C57BL/6J mice were randomized into 4 groups (n=12): Base, Ctrl, BTX, and BTX+Pan. The Base group was euthanized at study start. The BTX and BTX+Pan groups were immobilized by injections with BTX in one hind limb. The BTX+Pan group was injected i.p. daily with 100 mg pantoprazole per kg bodyweight. The mice were euthanized after 3 weeks of treatment. The skeletal status was investigated by DEXA, µCT, mechanical testing, dynamic bone histomorphometry, and RT-qPCR. The bone sites investigated were tibia, femur, L5 vertebra, and humerus.RESULTS: Injections of BTX induced a pronounced and significant loss of bone density, microstructure, and strength in the immobilized hind limb. Furthermore, the localized intramuscular injections of BTX lead to a slight loss of bone and bone strength at the L5 vertebra and humerus. Treatment with pantoprazole did not have any bone protective or deleterious effects.CONCLUSION: Pantoprazole was unable to prevent the development of BTX induced disuse osteopenia in skeletally mature female C57BL/6J mice.

AB - OBJECTIVES: Pantoprazole is a proton pump inhibitor that has been shown to inhibit bone resorption. The aim of the study was to investigate whether pantoprazole can prevent development of botulinum toxin (BTX)-induced disuse osteopenia in mice.METHODS: Forty-eight 16-week-old female C57BL/6J mice were randomized into 4 groups (n=12): Base, Ctrl, BTX, and BTX+Pan. The Base group was euthanized at study start. The BTX and BTX+Pan groups were immobilized by injections with BTX in one hind limb. The BTX+Pan group was injected i.p. daily with 100 mg pantoprazole per kg bodyweight. The mice were euthanized after 3 weeks of treatment. The skeletal status was investigated by DEXA, µCT, mechanical testing, dynamic bone histomorphometry, and RT-qPCR. The bone sites investigated were tibia, femur, L5 vertebra, and humerus.RESULTS: Injections of BTX induced a pronounced and significant loss of bone density, microstructure, and strength in the immobilized hind limb. Furthermore, the localized intramuscular injections of BTX lead to a slight loss of bone and bone strength at the L5 vertebra and humerus. Treatment with pantoprazole did not have any bone protective or deleterious effects.CONCLUSION: Pantoprazole was unable to prevent the development of BTX induced disuse osteopenia in skeletally mature female C57BL/6J mice.

KW - Journal Article

M3 - Journal article

C2 - 28860418

VL - 17

SP - 162

EP - 175

JO - Journal of Musculoskeletal and Neuronal Interactions

JF - Journal of Musculoskeletal and Neuronal Interactions

SN - 1108-7161

IS - 3

ER -