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Annemarie Brüel

Organ and tissue level properties are more sensitive to age than osteocyte lacunar characteristics in rat cortical bone

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Organ and tissue level properties are more sensitive to age than osteocyte lacunar characteristics in rat cortical bone. / Wittig, Nina; Bach-Gansmo, Fiona Linnea; Birkbak, Mie Elholm; Laugesen, Malene; Brüel, Annemarie; Thomsen, Jesper Skovhus; Birkedal, Henrik.

I: Bone Reports, Bind 4, 2016, s. 28-34.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{54cfd1354aa844de8dc76ac5ec6dff49,
title = "Organ and tissue level properties are more sensitive to age than osteocyte lacunar characteristics in rat cortical bone",
abstract = "Modeling and remodeling induce significant changes of bone structure and mechanical properties with age. Therefore, it is important to gain knowledge of the processes taking place in bone over time. The rat is a widely used animal model, where much data has been accumulated on age-related changes of bone on the organ and tissue level, whereas features on the nano- and micrometer scale are much less explored. We investigated the age-related development of organ and tissue level bone properties such as bone volume, bone mineral density, and load to fracture and correlated these with osteocyte lacunar properties in rat cortical bone. Femora of 14 to 42-week-old female Wistar rats were investigated using multiple complementary techniques including X-ray micro-computed tomography and biomechanical testing. The body weight, femoral length, aBMD, load to fracture, tissue volume, bone volume, and tissue density were found to increase rapidly with age at 14–30 weeks. At the age of 30–42 weeks, the growth rate appeared to decrease. However, no accompanying changes were found in osteocyte lacunar properties such as lacunar volume, ellipsoidal radii, lacunar stretch, lacunar oblateness, or lacunar orientation with animal age. Hence, the evolution of organ and tissue level properties with age in rat cortical bone is not accompanied by related changes in osteocyte lacunar properties. This suggests that bone microstructure and bone matrix material properties and not the geometric properties of the osteocyte lacunar network are main determinants of the properties of the bone on larger length scales.",
author = "Nina Wittig and Bach-Gansmo, {Fiona Linnea} and Birkbak, {Mie Elholm} and Malene Laugesen and Annemarie Br{\"u}el and Thomsen, {Jesper Skovhus} and Henrik Birkedal",
year = "2016",
doi = "10.1016/j.bonr.2015.11.003",
language = "English",
volume = "4",
pages = "28--34",
journal = "Bone Reports",
issn = "2352-1872",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Organ and tissue level properties are more sensitive to age than osteocyte lacunar characteristics in rat cortical bone

AU - Wittig, Nina

AU - Bach-Gansmo, Fiona Linnea

AU - Birkbak, Mie Elholm

AU - Laugesen, Malene

AU - Brüel, Annemarie

AU - Thomsen, Jesper Skovhus

AU - Birkedal, Henrik

PY - 2016

Y1 - 2016

N2 - Modeling and remodeling induce significant changes of bone structure and mechanical properties with age. Therefore, it is important to gain knowledge of the processes taking place in bone over time. The rat is a widely used animal model, where much data has been accumulated on age-related changes of bone on the organ and tissue level, whereas features on the nano- and micrometer scale are much less explored. We investigated the age-related development of organ and tissue level bone properties such as bone volume, bone mineral density, and load to fracture and correlated these with osteocyte lacunar properties in rat cortical bone. Femora of 14 to 42-week-old female Wistar rats were investigated using multiple complementary techniques including X-ray micro-computed tomography and biomechanical testing. The body weight, femoral length, aBMD, load to fracture, tissue volume, bone volume, and tissue density were found to increase rapidly with age at 14–30 weeks. At the age of 30–42 weeks, the growth rate appeared to decrease. However, no accompanying changes were found in osteocyte lacunar properties such as lacunar volume, ellipsoidal radii, lacunar stretch, lacunar oblateness, or lacunar orientation with animal age. Hence, the evolution of organ and tissue level properties with age in rat cortical bone is not accompanied by related changes in osteocyte lacunar properties. This suggests that bone microstructure and bone matrix material properties and not the geometric properties of the osteocyte lacunar network are main determinants of the properties of the bone on larger length scales.

AB - Modeling and remodeling induce significant changes of bone structure and mechanical properties with age. Therefore, it is important to gain knowledge of the processes taking place in bone over time. The rat is a widely used animal model, where much data has been accumulated on age-related changes of bone on the organ and tissue level, whereas features on the nano- and micrometer scale are much less explored. We investigated the age-related development of organ and tissue level bone properties such as bone volume, bone mineral density, and load to fracture and correlated these with osteocyte lacunar properties in rat cortical bone. Femora of 14 to 42-week-old female Wistar rats were investigated using multiple complementary techniques including X-ray micro-computed tomography and biomechanical testing. The body weight, femoral length, aBMD, load to fracture, tissue volume, bone volume, and tissue density were found to increase rapidly with age at 14–30 weeks. At the age of 30–42 weeks, the growth rate appeared to decrease. However, no accompanying changes were found in osteocyte lacunar properties such as lacunar volume, ellipsoidal radii, lacunar stretch, lacunar oblateness, or lacunar orientation with animal age. Hence, the evolution of organ and tissue level properties with age in rat cortical bone is not accompanied by related changes in osteocyte lacunar properties. This suggests that bone microstructure and bone matrix material properties and not the geometric properties of the osteocyte lacunar network are main determinants of the properties of the bone on larger length scales.

U2 - 10.1016/j.bonr.2015.11.003

DO - 10.1016/j.bonr.2015.11.003

M3 - Journal article

C2 - 28326340

VL - 4

SP - 28

EP - 34

JO - Bone Reports

JF - Bone Reports

SN - 2352-1872

ER -