Annemarie Brüel

Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone. / Bakalova, Lydia P; Andreasen, Christina M; Thomsen, Jesper Skovhus; Brüel, Annemarie; Hauge, Ellen-Margrethe; Kiil, Birgitte Jul; Delaisse, Jean-Marie; Andersen, Thomas Levin; Kersh, Mariana E.

I: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Bind 33, Nr. 12, 12.2018, s. 2177-2185.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Bakalova, LP, Andreasen, CM, Thomsen, JS, Brüel, A, Hauge, E-M, Kiil, BJ, Delaisse, J-M, Andersen, TL & Kersh, ME 2018, 'Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone', Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, bind 33, nr. 12, s. 2177-2185. https://doi.org/10.1002/jbmr.3561

APA

Bakalova, L. P., Andreasen, C. M., Thomsen, J. S., Brüel, A., Hauge, E-M., Kiil, B. J., Delaisse, J-M., Andersen, T. L., & Kersh, M. E. (2018). Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 33(12), 2177-2185. https://doi.org/10.1002/jbmr.3561

CBE

Bakalova LP, Andreasen CM, Thomsen JS, Brüel A, Hauge E-M, Kiil BJ, Delaisse J-M, Andersen TL, Kersh ME. 2018. Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 33(12):2177-2185. https://doi.org/10.1002/jbmr.3561

MLA

Bakalova, Lydia P o.a.. "Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone". Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2018, 33(12). 2177-2185. https://doi.org/10.1002/jbmr.3561

Vancouver

Bakalova LP, Andreasen CM, Thomsen JS, Brüel A, Hauge E-M, Kiil BJ o.a. Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2018 dec;33(12):2177-2185. https://doi.org/10.1002/jbmr.3561

Author

Bakalova, Lydia P ; Andreasen, Christina M ; Thomsen, Jesper Skovhus ; Brüel, Annemarie ; Hauge, Ellen-Margrethe ; Kiil, Birgitte Jul ; Delaisse, Jean-Marie ; Andersen, Thomas Levin ; Kersh, Mariana E. / Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone. I: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2018 ; Bind 33, Nr. 12. s. 2177-2185.

Bibtex

@article{a9c3563c0c0e4f6bb9be5beb0aca3800,
title = "Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone",
abstract = "During aging and in osteoporosis, cortical bone becomes more porous, making it more fragile and susceptible to fractures. The aim of this study was to investigate the intracortical compression- induced strain energy distribution, and determine whether intracortical pores associated with high strain energy density (SED) in the surrounding bone matrix have a different morphology, distribution and remodeling characteristics than matrix with normal SED. Fibular diaphyseal specimens from 20 patients undergoing a jaw reconstruction (age range 41-75 years, 14 men and 6 women) were studied. Bone specimens were µCT-scanned, plastic embedded, and sectioned for histology. Three-dimensional micro-finite element models of each specimen were tested in compression, and the SED of the bone immediately surrounding the intracortical pores was calculated within a plane of interest corresponding to the histological sections. The SED of a pore, relative to the distribution of the SED of all pores in each specimen, was used to classify pores as either a high or normal SED pore. Pores with high SED were larger, less circular, and were located closer to the endosteal surface of the cortex than normal SED pores (p < 0.001). Histological analysis of the remodeling events generating the pores revealed that the high SED pores compared to normal SED pores had a 13.3-fold higher odds of being an erosive (70%) or formative (7%) pore versus a quiescent pore (p < 0.001); a 5.9-fold higher odds of resulting from remodeling upon existing pores (type 2 pore) versus remodeling generating new pores (type 1 pore) (p < 0.001); and a 3.2-fold higher odds of being a coalescing type 2 pore versus a non-coalescing type 2 pore (p < 0.001). Overall, the study demonstrates a strong relationship between cortical bone mechanics and pore morphology, distribution, and remodeling characteristics in human fibular bone. This article is protected by copyright. All rights reserved.",
author = "Bakalova, {Lydia P} and Andreasen, {Christina M} and Thomsen, {Jesper Skovhus} and Annemarie Br{\"u}el and Ellen-Margrethe Hauge and Kiil, {Birgitte Jul} and Jean-Marie Delaisse and Andersen, {Thomas Levin} and Kersh, {Mariana E}",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
month = dec,
doi = "10.1002/jbmr.3561",
language = "English",
volume = "33",
pages = "2177--2185",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell Publishing, Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Intracortical Bone Mechanics Are Related to Pore Morphology and Remodeling in Human Bone

AU - Bakalova, Lydia P

AU - Andreasen, Christina M

AU - Thomsen, Jesper Skovhus

AU - Brüel, Annemarie

AU - Hauge, Ellen-Margrethe

AU - Kiil, Birgitte Jul

AU - Delaisse, Jean-Marie

AU - Andersen, Thomas Levin

AU - Kersh, Mariana E

N1 - This article is protected by copyright. All rights reserved.

PY - 2018/12

Y1 - 2018/12

N2 - During aging and in osteoporosis, cortical bone becomes more porous, making it more fragile and susceptible to fractures. The aim of this study was to investigate the intracortical compression- induced strain energy distribution, and determine whether intracortical pores associated with high strain energy density (SED) in the surrounding bone matrix have a different morphology, distribution and remodeling characteristics than matrix with normal SED. Fibular diaphyseal specimens from 20 patients undergoing a jaw reconstruction (age range 41-75 years, 14 men and 6 women) were studied. Bone specimens were µCT-scanned, plastic embedded, and sectioned for histology. Three-dimensional micro-finite element models of each specimen were tested in compression, and the SED of the bone immediately surrounding the intracortical pores was calculated within a plane of interest corresponding to the histological sections. The SED of a pore, relative to the distribution of the SED of all pores in each specimen, was used to classify pores as either a high or normal SED pore. Pores with high SED were larger, less circular, and were located closer to the endosteal surface of the cortex than normal SED pores (p < 0.001). Histological analysis of the remodeling events generating the pores revealed that the high SED pores compared to normal SED pores had a 13.3-fold higher odds of being an erosive (70%) or formative (7%) pore versus a quiescent pore (p < 0.001); a 5.9-fold higher odds of resulting from remodeling upon existing pores (type 2 pore) versus remodeling generating new pores (type 1 pore) (p < 0.001); and a 3.2-fold higher odds of being a coalescing type 2 pore versus a non-coalescing type 2 pore (p < 0.001). Overall, the study demonstrates a strong relationship between cortical bone mechanics and pore morphology, distribution, and remodeling characteristics in human fibular bone. This article is protected by copyright. All rights reserved.

AB - During aging and in osteoporosis, cortical bone becomes more porous, making it more fragile and susceptible to fractures. The aim of this study was to investigate the intracortical compression- induced strain energy distribution, and determine whether intracortical pores associated with high strain energy density (SED) in the surrounding bone matrix have a different morphology, distribution and remodeling characteristics than matrix with normal SED. Fibular diaphyseal specimens from 20 patients undergoing a jaw reconstruction (age range 41-75 years, 14 men and 6 women) were studied. Bone specimens were µCT-scanned, plastic embedded, and sectioned for histology. Three-dimensional micro-finite element models of each specimen were tested in compression, and the SED of the bone immediately surrounding the intracortical pores was calculated within a plane of interest corresponding to the histological sections. The SED of a pore, relative to the distribution of the SED of all pores in each specimen, was used to classify pores as either a high or normal SED pore. Pores with high SED were larger, less circular, and were located closer to the endosteal surface of the cortex than normal SED pores (p < 0.001). Histological analysis of the remodeling events generating the pores revealed that the high SED pores compared to normal SED pores had a 13.3-fold higher odds of being an erosive (70%) or formative (7%) pore versus a quiescent pore (p < 0.001); a 5.9-fold higher odds of resulting from remodeling upon existing pores (type 2 pore) versus remodeling generating new pores (type 1 pore) (p < 0.001); and a 3.2-fold higher odds of being a coalescing type 2 pore versus a non-coalescing type 2 pore (p < 0.001). Overall, the study demonstrates a strong relationship between cortical bone mechanics and pore morphology, distribution, and remodeling characteristics in human fibular bone. This article is protected by copyright. All rights reserved.

U2 - 10.1002/jbmr.3561

DO - 10.1002/jbmr.3561

M3 - Journal article

C2 - 30048570

VL - 33

SP - 2177

EP - 2185

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 12

ER -