Institut for Biomedicin

Annemarie Brüel

Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats. / Grubbe, M-C; Thomsen, Jesper Skovhus; Nyengaard, J R; Duruox, M; Brüel, A.

I: Journal of Musculoskeletal and Neuronal Interactions, Bind 14, Nr. 4, 12.2014, s. 473-83.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

APA

CBE

Grubbe M-C, Thomsen JS, Nyengaard JR, Duruox M, Brüel A. 2014. Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats. Journal of Musculoskeletal and Neuronal Interactions. 14(4):473-83.

MLA

Grubbe, M-C o.a.. "Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats". Journal of Musculoskeletal and Neuronal Interactions. 2014, 14(4). 473-83.

Vancouver

Grubbe M-C, Thomsen JS, Nyengaard JR, Duruox M, Brüel A. Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats. Journal of Musculoskeletal and Neuronal Interactions. 2014 dec;14(4):473-83.

Author

Grubbe, M-C ; Thomsen, Jesper Skovhus ; Nyengaard, J R ; Duruox, M ; Brüel, A. / Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats. I: Journal of Musculoskeletal and Neuronal Interactions. 2014 ; Bind 14, Nr. 4. s. 473-83.

Bibtex

@article{01145eb5e96649cda4d59c39a6efa430,
title = "Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats",
abstract = "Growth hormone (GH) is a potent anabolic agent capable of increasing both bone and muscle mass. The aim was to investigate whether GH could counteract disuse-induced loss of bone and muscle mass in a rat model. Paralysis was induced by injecting 4 IU Botox (BTX) into the muscles of the right hind limb. Sixty female Wistar rats, 14 weeks old, were divided into the following groups: baseline, controls, BTX, BTX+GH, and GH. GH was given at a dosage of 5 mg/kg/d for 4 weeks. Compared with controls, BTX resulted in lower periosteal bone formation rate (BFR/BS,-79%, P<0.001), bone mineral density (aBMD, -13%, P<0.001), trabecular bone volume (BV/TV, -26%, P<0.05), and mid-femoral bone strength (-12%, P<0.05). In addition, BTX reduced rectus femoris muscle mass (-69%, P<0.001) and muscle cell cross sectional area (CSA) (-73%, P<0.001) compared with controls. GH counteracted disuse-induced losses of periosteal BFR/BS (2-fold increase vs. BTX, P<0.001), whereas no effect on aBMD, trabecular BV/TV, or bone strength was found. In addition, GH partly prevented loss of muscle mass (+29% vs. BTX, P<0.001), and tended to prevent loss of muscle CSA (+11%, P=0.064). In conclusion, GH mitigates disuse-induced loss of periosteal BFR/BS at the mid-femur and rectus femoris muscle mass.",
author = "M-C Grubbe and Thomsen, {Jesper Skovhus} and Nyengaard, {J R} and M Duruox and A Br{\"u}el",
year = "2014",
month = dec,
language = "English",
volume = "14",
pages = "473--83",
journal = "Journal of Musculoskeletal and Neuronal Interactions",
issn = "1108-7161",
publisher = "The/International Society of Musculoskeletal and Neuronal Interactions",
number = "4",

}

RIS

TY - JOUR

T1 - Growth hormone mitigates loss of periosteal bone formation and muscle mass in disuse osteopenic rats

AU - Grubbe, M-C

AU - Thomsen, Jesper Skovhus

AU - Nyengaard, J R

AU - Duruox, M

AU - Brüel, A

PY - 2014/12

Y1 - 2014/12

N2 - Growth hormone (GH) is a potent anabolic agent capable of increasing both bone and muscle mass. The aim was to investigate whether GH could counteract disuse-induced loss of bone and muscle mass in a rat model. Paralysis was induced by injecting 4 IU Botox (BTX) into the muscles of the right hind limb. Sixty female Wistar rats, 14 weeks old, were divided into the following groups: baseline, controls, BTX, BTX+GH, and GH. GH was given at a dosage of 5 mg/kg/d for 4 weeks. Compared with controls, BTX resulted in lower periosteal bone formation rate (BFR/BS,-79%, P<0.001), bone mineral density (aBMD, -13%, P<0.001), trabecular bone volume (BV/TV, -26%, P<0.05), and mid-femoral bone strength (-12%, P<0.05). In addition, BTX reduced rectus femoris muscle mass (-69%, P<0.001) and muscle cell cross sectional area (CSA) (-73%, P<0.001) compared with controls. GH counteracted disuse-induced losses of periosteal BFR/BS (2-fold increase vs. BTX, P<0.001), whereas no effect on aBMD, trabecular BV/TV, or bone strength was found. In addition, GH partly prevented loss of muscle mass (+29% vs. BTX, P<0.001), and tended to prevent loss of muscle CSA (+11%, P=0.064). In conclusion, GH mitigates disuse-induced loss of periosteal BFR/BS at the mid-femur and rectus femoris muscle mass.

AB - Growth hormone (GH) is a potent anabolic agent capable of increasing both bone and muscle mass. The aim was to investigate whether GH could counteract disuse-induced loss of bone and muscle mass in a rat model. Paralysis was induced by injecting 4 IU Botox (BTX) into the muscles of the right hind limb. Sixty female Wistar rats, 14 weeks old, were divided into the following groups: baseline, controls, BTX, BTX+GH, and GH. GH was given at a dosage of 5 mg/kg/d for 4 weeks. Compared with controls, BTX resulted in lower periosteal bone formation rate (BFR/BS,-79%, P<0.001), bone mineral density (aBMD, -13%, P<0.001), trabecular bone volume (BV/TV, -26%, P<0.05), and mid-femoral bone strength (-12%, P<0.05). In addition, BTX reduced rectus femoris muscle mass (-69%, P<0.001) and muscle cell cross sectional area (CSA) (-73%, P<0.001) compared with controls. GH counteracted disuse-induced losses of periosteal BFR/BS (2-fold increase vs. BTX, P<0.001), whereas no effect on aBMD, trabecular BV/TV, or bone strength was found. In addition, GH partly prevented loss of muscle mass (+29% vs. BTX, P<0.001), and tended to prevent loss of muscle CSA (+11%, P=0.064). In conclusion, GH mitigates disuse-induced loss of periosteal BFR/BS at the mid-femur and rectus femoris muscle mass.

M3 - Journal article

C2 - 25524973

VL - 14

SP - 473

EP - 483

JO - Journal of Musculoskeletal and Neuronal Interactions

JF - Journal of Musculoskeletal and Neuronal Interactions

SN - 1108-7161

IS - 4

ER -