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Annemarie Brüel

Changes in 3-dimensional bone structure indices in hypoparathyroid patients treated with PTH(1-84): A randomized controlled study

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Hypoparathyroidism (hypoPT) is characterized by a state of low bone turnover and high bone mineral density (BMD) despite conventional treatment with calcium supplements and active vitamin D analogues. To assess effects of PTH substitution therapy on 3-dimensional bone structure, we randomized 62 patients with hypoPT into 24 weeks of treatment with either PTH(1-84) 100 µg/day subcutaneously or similar placebo as an add-on therapy. Micro-computed tomography was performed on 44 iliac crest bone biopsies (23 on PTH treatment) obtained after 24 weeks of treatment. Compared with placebo, PTH caused a 27% lower trabecular thickness (p 
OriginalsprogEngelsk
TidsskriftJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Vol/bind27
Nummer4
Sider (fra-til)781-8
Antal sider8
ISSN0884-0431
DOI
StatusUdgivet - 2012

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