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Anne Sofie Dam Laursen

Protein-rich food intake and risk of spontaneous abortion: a prospective cohort study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review


  • Amelia K. Wesselink, Boston University
  • ,
  • Sydney K. Willis, Boston University
  • ,
  • Anne Sofie Dam Laursen
  • Ellen M. Mikkelsen
  • Tanran R. Wang, Boston University
  • ,
  • Ellen Trolle, Danmarks Tekniske Universitet
  • ,
  • Katherine L. Tucker, University of Massachusetts Lowell
  • ,
  • Kenneth J. Rothman, Boston University, Research Triangle Institute International
  • ,
  • Lauren A. Wise, Boston University
  • ,
  • Elizabeth E. Hatch, Boston University

Purpose: Diet quality is increasingly recognized as important for human reproductive capacity. We studied the association between intake of protein-rich foods and risk of spontaneous abortion (SAB). Methods: During 2013–2020, we recruited pregnancy planners from the United States and Canada (Pregnancy Study Online; PRESTO) and Denmark (SnartForaeldre.dk; SF). Participants completed a baseline questionnaire and a validated cohort-specific food frequency questionnaire. We estimated preconception intake of red meat, poultry, processed meat, seafood, eggs, plant-based proteins, and dairy from individual foods and mixed recipes. We included 4,246 PRESTO and 2,953 SF participants who reported a pregnancy during the study. Data on SAB were derived from questionnaires and population registries. We used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CI), representing the effect of substituting one type of protein-rich food for another. Results: SAB risk was 23% in PRESTO and 16% in SF. In PRESTO, substitution of seafood with other protein-rich foods was associated with higher SAB risk [for example, the HR for replacing 100 g of seafood/week with 100 g of red meat was 1.10 (95% CI 1.00, 1.20)]. In contrast, in SF, substituting seafood with other protein-rich foods was associated with lower SAB risk [HR for replacing 100 g of seafood/week with 100 g of red meat was 0.89 (95% CI 0.82, 0.98)]. Other protein-rich food substitutions were not meaningfully associated with SAB risk. Conclusions: Preconception intake of protein-rich foods was largely unrelated to SAB risk, with the exception of seafood, which was associated with higher risk of SAB in Denmark, but a lower risk in North America.

TidsskriftEuropean Journal of Nutrition
Sider (fra-til)2737-2748
Antal sider12
StatusUdgivet - aug. 2022

Bibliografisk note

Funding Information:
This work was supported by NIH/NICHD grant R01-HD086742.

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.

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