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Anna Lorentzen

Single cell polarity in liquid phase facilitates tumour metastasis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Dokumenter

DOI

  • Anna Lorentzen
  • Paul F. Becker, Technische Universitat Munchen
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  • Jan Kosla, Technische Universitat Munchen, Czech Academy of Sciences, German Cancer Research Center
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  • Massimo Saini, German Cancer Research Center, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) GGmbH
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  • Kathrin Weidele, Fraunhofer-Institut für Toxikologie und Experimentelle Medizin
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  • Paolo Ronchi, European Molecular Biology Laboratory Heidelberg
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  • Corinna Klein, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) GGmbH
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  • Monika J. Wolf, University of Zurich
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  • Felix Geist, German Cancer Research Center, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) GGmbH
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  • Bastian Seubert, Technische Universitat Munchen, German Cancer Research Center
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  • Marc Ringelhan, Technische Universitat Munchen, Technical University of Munich
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  • Daniela Mihic-Probst, University of Zurich
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  • Knud Esser, Technische Universitat Munchen
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  • Marko Roblek, University of Zurich
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  • Felix Kuehne, Technische Universitat Munchen
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  • Gaia Bianco, Technische Universitat Munchen
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  • Tracy O'Connor, Technische Universitat Munchen, German Cancer Research Center
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  • Quentin Müller, Technical University of Munich
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  • Kathleen Schuck, Technical University of Munich
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  • Sebastian Lange, Technical University of Munich
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  • Daniel Hartmann, Technical University of Munich
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  • Saskia Spaich, University Medical Centre Mannheim
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  • Olaf Groß, Technical University of Munich
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  • Jochen Utikal, German Cancer Research Center, University Medical Center Mannheim
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  • Sebastian Haferkamp, University of Regensburg
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  • Martin R. Sprick, German Cancer Research Center, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) GGmbH
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  • Amruta Damle-Vartak, Leibnitz Research Cenrtre for Working Environment and Human Factors (IfADo)
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  • Alexander Hapfelmeier, Technical University of Munich
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  • Norbert Hüser, Technical University of Munich
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  • Ulrike Protzer, Technische Universitat Munchen
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  • Andreas Trumpp, German Cancer Research Center, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) GGmbH
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  • Dieter Saur, Technical University of Munich, German Cancer Research Center
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  • Nachiket Vartak, Leibnitz Research Cenrtre for Working Environment and Human Factors (IfADo)
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  • Christoph A. Klein, Fraunhofer-Institut für Toxikologie und Experimentelle Medizin, University of Regensburg
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  • Bernhard Polzer, Fraunhofer-Institut für Toxikologie und Experimentelle Medizin
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  • Lubor Borsig, University of Zurich
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  • Mathias Heikenwalder, Technische Universitat Munchen, German Cancer Research Center

Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from different tumour entities that is observed in circulating tumour cells in patients. Functionally, we propose that the sc pole is directly involved in early attachment, thereby affecting adhesion, transmigration and metastasis. In vivo, the metastatic capacity of cell lines correlates with the extent of sc polarisation. By manipulating sc polarity regulators and by generic depolarisation, we show that sc polarity prior to migration affects transmigration and metastasis in vitro and in vivo.

OriginalsprogEngelsk
Artikelnummer887
TidsskriftNature Communications
Vol/bind9
Nummer1
Antal sider20
ISSN2041-1723
DOI
StatusUdgivet - 1 dec. 2018

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