Understanding phagocytosis at the nm-level: The case of complement receptor 4

Aktivitet: Tale eller præsentation - typerForedrag og mundtlige bidrag

Se relationer på Aarhus Universitet

Thomas Vorup-Jensen - Foredragsholder

Phagocytosis is one of the most central processes in immunity to microbial infections. However, it is also a part of the ongoing clearance of aggregated, or otherwise decayed, macromolecular species, which needs removal to maintain tissue homeostasis in organs such as the brain. It is now well established that the innate immune system embodies several mechanisms for recognizing non-endogenous (“non-self”) molecules as targets. The principles of recognizing aggregated “self molecules” is, by contrast, far from clear. This lacuna in our knowledge owes much to the problems in following phagocytosis on a quantitative basis. Complement Receptor (CR) 4 belongs to the family of CD18 integrins and serve important roles cell adhesion and binding of structurally decayed proteins. Here, I discuss the application of nanotechnology to investigate the phagocytosis by this receptor, thereby unravelling a new principle in leukocyte recognition aggregated proteins relevant in neural disease.
23 aug. 2019

Begivenhed (Workshop)

Titel International Workshop on Advanced Biomedical Technologies
AfholdelsesstedAarhus University
ByAarhus C
Grad af anerkendelseInternational begivenhed


  • Nanomedicine, Immunology

ID: 164058366