White matter biomarkers from diffusion MRI

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

White matter biomarkers from diffusion MRI. / Jespersen, Sune.

In: Journal of Magnetic Resonance, 25.04.2018.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Jespersen, Sune. / White matter biomarkers from diffusion MRI. In: Journal of Magnetic Resonance. 2018.

Bibtex

@article{5e60feb334b142aeb7befc86a6880216,
title = "White matter biomarkers from diffusion MRI",
abstract = "Abstract As part of an issue celebrating 2 decades of Joseph Ackerman editing the Journal of Magnetic Resonance, this paper reviews recent progress in one of the many areas in which Ackerman and his lab has made significant contributions: NMR measurement of diffusion in biological media, specifically in brain tissue. NMR diffusion signals display exquisite sensitivity to tissue microstructure, and have the potential to offer quantitative and specific information on the cellular scale orders of magnitude below nominal image resolution when combined with biophysical modeling. Here, I offer a personal perspective on some recent advances in diffusion imaging, from diffusion kurtosis imaging to microstructural modeling, and the connection between the two. A new result on the estimation accuracy of axial and radial kurtosis with axially symmetric DKI is presented. I moreover touch upon recently suggested generalized diffusion sequences, promising to offer independent microstructural information. We discuss the need and some methods for validation, and end with an outlook on some promising future directions.",
keywords = "Diffusion, Microstructure, White matter, Kurtosis, Double diffusion encoding, Isotropic diffusion encoding, Modeling",
author = "Sune Jespersen",
year = "2018",
month = "4",
day = "25",
doi = "10.1016/j.jmr.2018.03.001",
language = "Dansk",
journal = "Journal of Magnetic Resonance",
issn = "1090-7807",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - White matter biomarkers from diffusion MRI

AU - Jespersen, Sune

PY - 2018/4/25

Y1 - 2018/4/25

N2 - Abstract As part of an issue celebrating 2 decades of Joseph Ackerman editing the Journal of Magnetic Resonance, this paper reviews recent progress in one of the many areas in which Ackerman and his lab has made significant contributions: NMR measurement of diffusion in biological media, specifically in brain tissue. NMR diffusion signals display exquisite sensitivity to tissue microstructure, and have the potential to offer quantitative and specific information on the cellular scale orders of magnitude below nominal image resolution when combined with biophysical modeling. Here, I offer a personal perspective on some recent advances in diffusion imaging, from diffusion kurtosis imaging to microstructural modeling, and the connection between the two. A new result on the estimation accuracy of axial and radial kurtosis with axially symmetric DKI is presented. I moreover touch upon recently suggested generalized diffusion sequences, promising to offer independent microstructural information. We discuss the need and some methods for validation, and end with an outlook on some promising future directions.

AB - Abstract As part of an issue celebrating 2 decades of Joseph Ackerman editing the Journal of Magnetic Resonance, this paper reviews recent progress in one of the many areas in which Ackerman and his lab has made significant contributions: NMR measurement of diffusion in biological media, specifically in brain tissue. NMR diffusion signals display exquisite sensitivity to tissue microstructure, and have the potential to offer quantitative and specific information on the cellular scale orders of magnitude below nominal image resolution when combined with biophysical modeling. Here, I offer a personal perspective on some recent advances in diffusion imaging, from diffusion kurtosis imaging to microstructural modeling, and the connection between the two. A new result on the estimation accuracy of axial and radial kurtosis with axially symmetric DKI is presented. I moreover touch upon recently suggested generalized diffusion sequences, promising to offer independent microstructural information. We discuss the need and some methods for validation, and end with an outlook on some promising future directions.

KW - Diffusion

KW - Microstructure

KW - White matter

KW - Kurtosis

KW - Double diffusion encoding

KW - Isotropic diffusion encoding

KW - Modeling

U2 - 10.1016/j.jmr.2018.03.001

DO - 10.1016/j.jmr.2018.03.001

M3 - Tidsskriftartikel

JO - Journal of Magnetic Resonance

T2 - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

SN - 1090-7807

ER -