Stability of amphetamine impurity profiles during 12 months of storage

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Stability of amphetamine impurity profiles during 12 months of storage. / Nielsen, Louise Stride; Villesen, Palle; Lindholst, Christian.

In: Forensic Science International, Vol. 290, 05.07.2018, p. 129-136.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Nielsen, LS, Villesen, P & Lindholst, C 2018, 'Stability of amphetamine impurity profiles during 12 months of storage' Forensic Science International, vol. 290, pp. 129-136.

APA

Nielsen, L. S., Villesen, P., & Lindholst, C. (2018). Stability of amphetamine impurity profiles during 12 months of storage. Forensic Science International, 290, 129-136.

CBE

Nielsen LS, Villesen P, Lindholst C. 2018. Stability of amphetamine impurity profiles during 12 months of storage. Forensic Science International. 290:129-136.

MLA

Nielsen, Louise Stride, Palle Villesen, and Christian Lindholst. "Stability of amphetamine impurity profiles during 12 months of storage". Forensic Science International. 2018, 290. 129-136.

Vancouver

Nielsen LS, Villesen P, Lindholst C. Stability of amphetamine impurity profiles during 12 months of storage. Forensic Science International. 2018 Jul 5;290:129-136.

Author

Nielsen, Louise Stride ; Villesen, Palle ; Lindholst, Christian. / Stability of amphetamine impurity profiles during 12 months of storage. In: Forensic Science International. 2018 ; Vol. 290. pp. 129-136

Bibtex

@article{dcfc6133d72b4971bd43f13506163f45,
title = "Stability of amphetamine impurity profiles during 12 months of storage",
abstract = "Impurity profiling is a well described forensic tool that may be applied to gain information about the illegal drug market. However, it requires experience to assess the correlation between chemical profiles thereby separating linked from unlinked samples. One of the challenges in this context is that the chemical profiles may change over time, thus complicating an assessment if samples are stored under different conditions. In this study, the impact of different storage conditions on the stability of amphetamine impurity profiles was investigated. We examined the influence of storage time, temperature, sample purity, sample quantity and the presence of methanol on the amphetamine profile stability when stored for up to 12 months.We find that the target compounds in amphetamine impurity profiles are susceptible to all the examined storage conditions. Consequently, this unstable nature of amphetamine profiles may complicate the assessment when comparing amphetamine seizures that has been separated for longer time periods or stored under different conditions prior to seizure. Knowledge about the seizure history is rarely available to the forensic analyst. Therefore, sample stability issues should be taken into account when comparisons of chemical profiles are made.",
author = "Nielsen, {Louise Stride} and Palle Villesen and Christian Lindholst",
year = "2018",
month = "7",
day = "5",
language = "English",
volume = "290",
pages = "129--136",
journal = "Forensic Science International",
issn = "0379-0738",
publisher = "Elsevier Ireland Ltd.",

}

RIS

TY - JOUR

T1 - Stability of amphetamine impurity profiles during 12 months of storage

AU - Nielsen,Louise Stride

AU - Villesen,Palle

AU - Lindholst,Christian

PY - 2018/7/5

Y1 - 2018/7/5

N2 - Impurity profiling is a well described forensic tool that may be applied to gain information about the illegal drug market. However, it requires experience to assess the correlation between chemical profiles thereby separating linked from unlinked samples. One of the challenges in this context is that the chemical profiles may change over time, thus complicating an assessment if samples are stored under different conditions. In this study, the impact of different storage conditions on the stability of amphetamine impurity profiles was investigated. We examined the influence of storage time, temperature, sample purity, sample quantity and the presence of methanol on the amphetamine profile stability when stored for up to 12 months.We find that the target compounds in amphetamine impurity profiles are susceptible to all the examined storage conditions. Consequently, this unstable nature of amphetamine profiles may complicate the assessment when comparing amphetamine seizures that has been separated for longer time periods or stored under different conditions prior to seizure. Knowledge about the seizure history is rarely available to the forensic analyst. Therefore, sample stability issues should be taken into account when comparisons of chemical profiles are made.

AB - Impurity profiling is a well described forensic tool that may be applied to gain information about the illegal drug market. However, it requires experience to assess the correlation between chemical profiles thereby separating linked from unlinked samples. One of the challenges in this context is that the chemical profiles may change over time, thus complicating an assessment if samples are stored under different conditions. In this study, the impact of different storage conditions on the stability of amphetamine impurity profiles was investigated. We examined the influence of storage time, temperature, sample purity, sample quantity and the presence of methanol on the amphetamine profile stability when stored for up to 12 months.We find that the target compounds in amphetamine impurity profiles are susceptible to all the examined storage conditions. Consequently, this unstable nature of amphetamine profiles may complicate the assessment when comparing amphetamine seizures that has been separated for longer time periods or stored under different conditions prior to seizure. Knowledge about the seizure history is rarely available to the forensic analyst. Therefore, sample stability issues should be taken into account when comparisons of chemical profiles are made.

M3 - Journal article

VL - 290

SP - 129

EP - 136

JO - Forensic Science International

T2 - Forensic Science International

JF - Forensic Science International

SN - 0379-0738

ER -