New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain

Publication: Research - peer-reviewReview

Standard

New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain. / Feldman, Eva L; Nave, Klaus-Armin; Jensen, Troels Staehelin; Bennett, David L H.

In: Neuron, Vol. 93, No. 6, 03.2017, p. 1296-1313.

Publication: Research - peer-reviewReview

Harvard

Feldman, EL, Nave, K-A, Jensen, TS & Bennett, DLH 2017, 'New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain' Neuron, vol 93, no. 6, pp. 1296-1313. DOI: 10.1016/j.neuron.2017.02.005

APA

Feldman, E. L., Nave, K-A., Jensen, T. S., & Bennett, D. L. H. (2017). New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain. Neuron, 93(6), 1296-1313. DOI: 10.1016/j.neuron.2017.02.005

CBE

Feldman EL, Nave K-A, Jensen TS, Bennett DLH. 2017. New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain. Neuron. 93(6):1296-1313. Available from: 10.1016/j.neuron.2017.02.005

MLA

Vancouver

Feldman EL, Nave K-A, Jensen TS, Bennett DLH. New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain. Neuron. 2017 Mar;93(6):1296-1313. Available from, DOI: 10.1016/j.neuron.2017.02.005

Author

Feldman, Eva L; Nave, Klaus-Armin; Jensen, Troels Staehelin; Bennett, David L H / New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain.

In: Neuron, Vol. 93, No. 6, 03.2017, p. 1296-1313.

Publication: Research - peer-reviewReview

Bibtex

@article{b9ea636e8af648b7a69ba72cf81a308c,
title = "New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain",
keywords = "Journal Article, Review",
author = "Feldman, {Eva L} and Klaus-Armin Nave and Jensen, {Troels Staehelin} and Bennett, {David L H}",
note = "Copyright © 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = "3",
doi = "10.1016/j.neuron.2017.02.005",
volume = "93",
pages = "1296--1313",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain

AU - Feldman,Eva L

AU - Nave,Klaus-Armin

AU - Jensen,Troels Staehelin

AU - Bennett,David L H

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/3

Y1 - 2017/3

N2 - Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic complications create a substantial burden on both the afflicted patients and society as a whole. Given the enormity of the problem and the lack of effective therapies, there is a pressing need to understand the mechanisms underlying diabetic neuropathy (DN). In this review, we present the structural components of the peripheral nervous system that underlie its susceptibility to metabolic insults and then discuss the pathways that contribute to peripheral nerve injury in DN. We also discuss systems biology insights gleaned from the recent advances in biotechnology and bioinformatics, emerging ideas centered on the axon-Schwann cell relationship and associated bioenergetic crosstalk, and the rapid expansion of our knowledge of the mechanisms contributing to neuropathic pain in diabetes. These recent advances in our understanding of DN pathogenesis are paving the way for critical mechanism-based therapy development.

AB - Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic complications create a substantial burden on both the afflicted patients and society as a whole. Given the enormity of the problem and the lack of effective therapies, there is a pressing need to understand the mechanisms underlying diabetic neuropathy (DN). In this review, we present the structural components of the peripheral nervous system that underlie its susceptibility to metabolic insults and then discuss the pathways that contribute to peripheral nerve injury in DN. We also discuss systems biology insights gleaned from the recent advances in biotechnology and bioinformatics, emerging ideas centered on the axon-Schwann cell relationship and associated bioenergetic crosstalk, and the rapid expansion of our knowledge of the mechanisms contributing to neuropathic pain in diabetes. These recent advances in our understanding of DN pathogenesis are paving the way for critical mechanism-based therapy development.

KW - Journal Article

KW - Review

U2 - 10.1016/j.neuron.2017.02.005

DO - 10.1016/j.neuron.2017.02.005

M3 - Review

VL - 93

SP - 1296

EP - 1313

JO - Neuron

T2 - Neuron

JF - Neuron

SN - 0896-6273

IS - 6

ER -