New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain

Publication: Research - peer-reviewReview


  • Eva L Feldman
    Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, MI
  • Klaus-Armin Nave
    Klaus-Armin NaveDepartment of Neurogenetics, Max Planck Institute for Experimental Medicine, Göttingen
  • Troels Staehelin Jensen
  • David L H Bennett
    David L H BennettNuffield Department of Clinical Neuroscience, University of Oxford, Oxford

Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic complications create a substantial burden on both the afflicted patients and society as a whole. Given the enormity of the problem and the lack of effective therapies, there is a pressing need to understand the mechanisms underlying diabetic neuropathy (DN). In this review, we present the structural components of the peripheral nervous system that underlie its susceptibility to metabolic insults and then discuss the pathways that contribute to peripheral nerve injury in DN. We also discuss systems biology insights gleaned from the recent advances in biotechnology and bioinformatics, emerging ideas centered on the axon-Schwann cell relationship and associated bioenergetic crosstalk, and the rapid expansion of our knowledge of the mechanisms contributing to neuropathic pain in diabetes. These recent advances in our understanding of DN pathogenesis are paving the way for critical mechanism-based therapy development.

Original languageEnglish
Issue number6
Pages (from-to)1296-1313
StatePublished - Mar 2017


  • Journal Article, Review

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