Ischemic stroke subtype is associated with outcome in thrombolyzed patients

Publication: Research - peer-reviewJournal article

Standard

Ischemic stroke subtype is associated with outcome in thrombolyzed patients. / Schmitz, Marie Louise; Simonsen, Claus Ziegler; Svendsen, M L; Larsson, Heidi Jeanet; Hjørringgaard Madsen, Mette; Mikkelsen, I K; Fisher, M; Johnsen, Søren Paaske; Andersen, Grethe.

In: Acta Neurologica Scandinavica. Supplementum, Vol. 135, No. 2, 02.2017, p. 176-182.

Publication: Research - peer-reviewJournal article

Harvard

Schmitz, ML, Simonsen, CZ, Svendsen, ML, Larsson, HJ, Hjørringgaard Madsen, M, Mikkelsen, IK, Fisher, M, Johnsen, SP & Andersen, G 2017, 'Ischemic stroke subtype is associated with outcome in thrombolyzed patients' Acta Neurologica Scandinavica. Supplementum, vol 135, no. 2, pp. 176-182. DOI: 10.1111/ane.12589

APA

Schmitz, M. L., Simonsen, C. Z., Svendsen, M. L., Larsson, H. J., Hjørringgaard Madsen, M., Mikkelsen, I. K., ... Andersen, G. (2017). Ischemic stroke subtype is associated with outcome in thrombolyzed patients. Acta Neurologica Scandinavica. Supplementum, 135(2), 176-182. DOI: 10.1111/ane.12589

CBE

Schmitz ML, Simonsen CZ, Svendsen ML, Larsson HJ, Hjørringgaard Madsen M, Mikkelsen IK, Fisher M, Johnsen SP, Andersen G. 2017. Ischemic stroke subtype is associated with outcome in thrombolyzed patients. Acta Neurologica Scandinavica. Supplementum. 135(2):176-182. Available from: 10.1111/ane.12589

MLA

Schmitz, Marie Louise et al."Ischemic stroke subtype is associated with outcome in thrombolyzed patients". Acta Neurologica Scandinavica. Supplementum. 2017, 135(2). 176-182. Available: 10.1111/ane.12589

Vancouver

Schmitz ML, Simonsen CZ, Svendsen ML, Larsson HJ, Hjørringgaard Madsen M, Mikkelsen IK et al. Ischemic stroke subtype is associated with outcome in thrombolyzed patients. Acta Neurologica Scandinavica. Supplementum. 2017 Feb;135(2):176-182. Available from, DOI: 10.1111/ane.12589

Author

Schmitz, Marie Louise; Simonsen, Claus Ziegler; Svendsen, M L; Larsson, Heidi Jeanet; Hjørringgaard Madsen, Mette; Mikkelsen, I K; Fisher, M; Johnsen, Søren Paaske; Andersen, Grethe / Ischemic stroke subtype is associated with outcome in thrombolyzed patients.

In: Acta Neurologica Scandinavica. Supplementum, Vol. 135, No. 2, 02.2017, p. 176-182.

Publication: Research - peer-reviewJournal article

Bibtex

@article{0fac788c7fe5411a8b47055c409396d6,
title = "Ischemic stroke subtype is associated with outcome in thrombolyzed patients",
abstract = "OBJECTIVES: The impact of ischemic stroke subtype on clinical outcome in patients treated with intravenous tissue-type plasminogen activator (IV-tPA) is sparsely examined. We studied the association between stroke subtype and clinical outcome in magnetic resonance imaging (MRI)-evaluated patients treated with IV-tPA.MATERIAL AND METHODS: We conducted a single-center retrospective analysis of MRI-selected stroke patients treated with IV-tPA between 2004 and 2010. The Trial of ORG 10172 in Acute Stroke Treatment criteria were used to establish the stroke subtype by 3 months. The outcomes of interest were a 3-month modified Rankin Scale score of 0-1 (favorable outcome), and early neurological improvement defined as complete remission of neurological deficit or improvement of ≥4 on the National Institute of Health Stroke Scale at 24 h. The outcomes among stroke subtypes were compared with multivariable logistic regression.RESULTS:Among 557 patients, 202 (36%) had large vessel disease (LVD), 153 (27%) cardioembolic stroke (CE), 109 (20%) small vessel disease, and 93 (17%) were of other or undetermined etiology. Early neurological improvement was present in 313 (56.4%) patients, and 361 (64.8%) patients achieved a favorable outcome. Early neurological improvement and favorable outcome were more likely in CE patients compared with LVD patients (odds ratio (OR), 2.1 (95% confidence interval, 1.4-3.3), and 2.0 (95% confidence interval, 1.2-3.3), respectively).CONCLUSIONS: Cardioembolic stroke patients were more likely to achieve early neurological improvement and favorable outcome compared with LVD stroke following MRI-based IV-tPA treatment. This finding may reflect a difference in the effect of IV-tPA among stroke subtypes.",
author = "Schmitz, {Marie Louise} and Simonsen, {Claus Ziegler} and Svendsen, {M L} and Larsson, {Heidi Jeanet} and {Hjørringgaard Madsen}, Mette and Mikkelsen, {I K} and M Fisher and Johnsen, {Søren Paaske} and Grethe Andersen",
note = "© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2017",
month = "2",
doi = "10.1111/ane.12589",
volume = "135",
pages = "176--182",
journal = "Acta Neurologica Scandinavica. Supplementum",
issn = "0065-1427",
publisher = "Wiley-Blackwell Publishing, Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Ischemic stroke subtype is associated with outcome in thrombolyzed patients

AU - Schmitz,Marie Louise

AU - Simonsen,Claus Ziegler

AU - Svendsen,M L

AU - Larsson,Heidi Jeanet

AU - Hjørringgaard Madsen,Mette

AU - Mikkelsen,I K

AU - Fisher,M

AU - Johnsen,Søren Paaske

AU - Andersen,Grethe

N1 - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2017/2

Y1 - 2017/2

N2 - OBJECTIVES: The impact of ischemic stroke subtype on clinical outcome in patients treated with intravenous tissue-type plasminogen activator (IV-tPA) is sparsely examined. We studied the association between stroke subtype and clinical outcome in magnetic resonance imaging (MRI)-evaluated patients treated with IV-tPA.MATERIAL AND METHODS: We conducted a single-center retrospective analysis of MRI-selected stroke patients treated with IV-tPA between 2004 and 2010. The Trial of ORG 10172 in Acute Stroke Treatment criteria were used to establish the stroke subtype by 3 months. The outcomes of interest were a 3-month modified Rankin Scale score of 0-1 (favorable outcome), and early neurological improvement defined as complete remission of neurological deficit or improvement of ≥4 on the National Institute of Health Stroke Scale at 24 h. The outcomes among stroke subtypes were compared with multivariable logistic regression.RESULTS:Among 557 patients, 202 (36%) had large vessel disease (LVD), 153 (27%) cardioembolic stroke (CE), 109 (20%) small vessel disease, and 93 (17%) were of other or undetermined etiology. Early neurological improvement was present in 313 (56.4%) patients, and 361 (64.8%) patients achieved a favorable outcome. Early neurological improvement and favorable outcome were more likely in CE patients compared with LVD patients (odds ratio (OR), 2.1 (95% confidence interval, 1.4-3.3), and 2.0 (95% confidence interval, 1.2-3.3), respectively).CONCLUSIONS: Cardioembolic stroke patients were more likely to achieve early neurological improvement and favorable outcome compared with LVD stroke following MRI-based IV-tPA treatment. This finding may reflect a difference in the effect of IV-tPA among stroke subtypes.

AB - OBJECTIVES: The impact of ischemic stroke subtype on clinical outcome in patients treated with intravenous tissue-type plasminogen activator (IV-tPA) is sparsely examined. We studied the association between stroke subtype and clinical outcome in magnetic resonance imaging (MRI)-evaluated patients treated with IV-tPA.MATERIAL AND METHODS: We conducted a single-center retrospective analysis of MRI-selected stroke patients treated with IV-tPA between 2004 and 2010. The Trial of ORG 10172 in Acute Stroke Treatment criteria were used to establish the stroke subtype by 3 months. The outcomes of interest were a 3-month modified Rankin Scale score of 0-1 (favorable outcome), and early neurological improvement defined as complete remission of neurological deficit or improvement of ≥4 on the National Institute of Health Stroke Scale at 24 h. The outcomes among stroke subtypes were compared with multivariable logistic regression.RESULTS:Among 557 patients, 202 (36%) had large vessel disease (LVD), 153 (27%) cardioembolic stroke (CE), 109 (20%) small vessel disease, and 93 (17%) were of other or undetermined etiology. Early neurological improvement was present in 313 (56.4%) patients, and 361 (64.8%) patients achieved a favorable outcome. Early neurological improvement and favorable outcome were more likely in CE patients compared with LVD patients (odds ratio (OR), 2.1 (95% confidence interval, 1.4-3.3), and 2.0 (95% confidence interval, 1.2-3.3), respectively).CONCLUSIONS: Cardioembolic stroke patients were more likely to achieve early neurological improvement and favorable outcome compared with LVD stroke following MRI-based IV-tPA treatment. This finding may reflect a difference in the effect of IV-tPA among stroke subtypes.

U2 - 10.1111/ane.12589

DO - 10.1111/ane.12589

M3 - Journal article

VL - 135

SP - 176

EP - 182

JO - Acta Neurologica Scandinavica. Supplementum

T2 - Acta Neurologica Scandinavica. Supplementum

JF - Acta Neurologica Scandinavica. Supplementum

SN - 0065-1427

IS - 2

ER -