Ischemic stroke subtype is associated with outcome in thrombolyzed patients

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Ischemic stroke subtype is associated with outcome in thrombolyzed patients. / Schmitz, Marie Louise; Simonsen, Claus Ziegler ; Svendsen, M L; Larsson, Heidi Jeanet; Hjørringgaard Madsen, Mette; Mikkelsen, I K; Fisher, M; Johnsen, Søren Paaske ; Andersen, Grethe.

In: Acta Neurologica Scandinavica. Supplementum, Vol. 135, No. 2, 02.2017, p. 176-182.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article

MLA

Schmitz, Marie Louise et al."Ischemic stroke subtype is associated with outcome in thrombolyzed patients". Acta Neurologica Scandinavica. Supplementum. 2017, 135(2). 176-182. Available: 10.1111/ane.12589

Vancouver

Schmitz ML, Simonsen CZ , Svendsen ML, Larsson HJ, Hjørringgaard Madsen M, Mikkelsen IK et al. Ischemic stroke subtype is associated with outcome in thrombolyzed patients. Acta Neurologica Scandinavica. Supplementum. 2017 Feb;135(2):176-182. Available from, DOI: 10.1111/ane.12589

Author

Schmitz, Marie Louise ; Simonsen, Claus Ziegler ; Svendsen, M L ; Larsson, Heidi Jeanet ; Hjørringgaard Madsen, Mette ; Mikkelsen, I K ; Fisher, M ; Johnsen, Søren Paaske ; Andersen, Grethe. / Ischemic stroke subtype is associated with outcome in thrombolyzed patients. In: Acta Neurologica Scandinavica. Supplementum. 2017 ; Vol. 135, No. 2. pp. 176-182

Bibtex

@article{0fac788c7fe5411a8b47055c409396d6,

title = "Ischemic stroke subtype is associated with outcome in thrombolyzed patients",

abstract = "OBJECTIVES: The impact of ischemic stroke subtype on clinical outcome in patients treated with intravenous tissue-type plasminogen activator (IV-tPA) is sparsely examined. We studied the association between stroke subtype and clinical outcome in magnetic resonance imaging (MRI)-evaluated patients treated with IV-tPA.MATERIAL AND METHODS: We conducted a single-center retrospective analysis of MRI-selected stroke patients treated with IV-tPA between 2004 and 2010. The Trial of ORG 10172 in Acute Stroke Treatment criteria were used to establish the stroke subtype by 3 months. The outcomes of interest were a 3-month modified Rankin Scale score of 0-1 (favorable outcome), and early neurological improvement defined as complete remission of neurological deficit or improvement of ≥4 on the National Institute of Health Stroke Scale at 24 h. The outcomes among stroke subtypes were compared with multivariable logistic regression.RESULTS:Among 557 patients, 202 (36{\%}) had large vessel disease (LVD), 153 (27{\%}) cardioembolic stroke (CE), 109 (20{\%}) small vessel disease, and 93 (17{\%}) were of other or undetermined etiology. Early neurological improvement was present in 313 (56.4{\%}) patients, and 361 (64.8{\%}) patients achieved a favorable outcome. Early neurological improvement and favorable outcome were more likely in CE patients compared with LVD patients (odds ratio (OR), 2.1 (95{\%} confidence interval, 1.4-3.3), and 2.0 (95{\%} confidence interval, 1.2-3.3), respectively).CONCLUSIONS: Cardioembolic stroke patients were more likely to achieve early neurological improvement and favorable outcome compared with LVD stroke following MRI-based IV-tPA treatment. This finding may reflect a difference in the effect of IV-tPA among stroke subtypes.",

author = "Schmitz, {Marie Louise} and Simonsen, {Claus Ziegler} and Svendsen, {M L} and Larsson, {Heidi Jeanet} and {Hj{\o}rringgaard Madsen}, Mette and Mikkelsen, {I K} and M Fisher and Johnsen, {S{\o}ren Paaske} and Grethe Andersen",

note = "{\circledC} 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2017",

month = "2",

doi = "10.1111/ane.12589",

language = "English",

volume = "135",

pages = "176--182",

journal = "Acta Neurologica Scandinavica. Supplementum",

issn = "0065-1427",

publisher = "Wiley-Blackwell Publishing, Inc",

number = "2",

}

RIS

TY - JOUR

T1 - Ischemic stroke subtype is associated with outcome in thrombolyzed patients

AU - Schmitz,Marie Louise

AU - Simonsen,Claus Ziegler

AU - Svendsen,M L

AU - Larsson,Heidi Jeanet

AU - Hjørringgaard Madsen,Mette

AU - Mikkelsen,I K

AU - Fisher,M

AU - Johnsen,Søren Paaske

AU - Andersen,Grethe

PY - 2017/2

Y1 - 2017/2

N2 - OBJECTIVES: The impact of ischemic stroke subtype on clinical outcome in patients treated with intravenous tissue-type plasminogen activator (IV-tPA) is sparsely examined. We studied the association between stroke subtype and clinical outcome in magnetic resonance imaging (MRI)-evaluated patients treated with IV-tPA.MATERIAL AND METHODS: We conducted a single-center retrospective analysis of MRI-selected stroke patients treated with IV-tPA between 2004 and 2010. The Trial of ORG 10172 in Acute Stroke Treatment criteria were used to establish the stroke subtype by 3 months. The outcomes of interest were a 3-month modified Rankin Scale score of 0-1 (favorable outcome), and early neurological improvement defined as complete remission of neurological deficit or improvement of ≥4 on the National Institute of Health Stroke Scale at 24 h. The outcomes among stroke subtypes were compared with multivariable logistic regression.RESULTS:Among 557 patients, 202 (36%) had large vessel disease (LVD), 153 (27%) cardioembolic stroke (CE), 109 (20%) small vessel disease, and 93 (17%) were of other or undetermined etiology. Early neurological improvement was present in 313 (56.4%) patients, and 361 (64.8%) patients achieved a favorable outcome. Early neurological improvement and favorable outcome were more likely in CE patients compared with LVD patients (odds ratio (OR), 2.1 (95% confidence interval, 1.4-3.3), and 2.0 (95% confidence interval, 1.2-3.3), respectively).CONCLUSIONS: Cardioembolic stroke patients were more likely to achieve early neurological improvement and favorable outcome compared with LVD stroke following MRI-based IV-tPA treatment. This finding may reflect a difference in the effect of IV-tPA among stroke subtypes.

AB - OBJECTIVES: The impact of ischemic stroke subtype on clinical outcome in patients treated with intravenous tissue-type plasminogen activator (IV-tPA) is sparsely examined. We studied the association between stroke subtype and clinical outcome in magnetic resonance imaging (MRI)-evaluated patients treated with IV-tPA.MATERIAL AND METHODS: We conducted a single-center retrospective analysis of MRI-selected stroke patients treated with IV-tPA between 2004 and 2010. The Trial of ORG 10172 in Acute Stroke Treatment criteria were used to establish the stroke subtype by 3 months. The outcomes of interest were a 3-month modified Rankin Scale score of 0-1 (favorable outcome), and early neurological improvement defined as complete remission of neurological deficit or improvement of ≥4 on the National Institute of Health Stroke Scale at 24 h. The outcomes among stroke subtypes were compared with multivariable logistic regression.RESULTS:Among 557 patients, 202 (36%) had large vessel disease (LVD), 153 (27%) cardioembolic stroke (CE), 109 (20%) small vessel disease, and 93 (17%) were of other or undetermined etiology. Early neurological improvement was present in 313 (56.4%) patients, and 361 (64.8%) patients achieved a favorable outcome. Early neurological improvement and favorable outcome were more likely in CE patients compared with LVD patients (odds ratio (OR), 2.1 (95% confidence interval, 1.4-3.3), and 2.0 (95% confidence interval, 1.2-3.3), respectively).CONCLUSIONS: Cardioembolic stroke patients were more likely to achieve early neurological improvement and favorable outcome compared with LVD stroke following MRI-based IV-tPA treatment. This finding may reflect a difference in the effect of IV-tPA among stroke subtypes.

U2 - 10.1111/ane.12589

DO - 10.1111/ane.12589

M3 - Journal article

VL - 135

SP - 176

EP - 182

JO - Acta Neurologica Scandinavica. Supplementum

T2 - Acta Neurologica Scandinavica. Supplementum

JF - Acta Neurologica Scandinavica. Supplementum

SN - 0065-1427

IS - 2

ER -