Long-term outcome of microscopic esophagitis in chronic GERD patients treated with esomeprazole or laparoscopic antireflux surgery in the LOTUS trial

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Roberto Fiocca
  • ,
  • Luca Mastracci
  • ,
  • Cecilia Engström
  • ,
  • Stephen Attwood
  • ,
  • Christian Ell
  • ,
  • Jean-Paul Galmiche
  • ,
  • Jan Hatlebakk
  • ,
  • Ola Junghard
  • ,
  • Tore Lind
  • ,
  • Lars Lundell
  • ,
  • LOTUS trial collaborators
  • ,
  • Peter Funch-Jensen
  • Institute of Clinical Medicine
  • The Department of Surgical Gastroenterology L
Gastroesophageal reflux disease (GERD)-associated changes in esophageal histology have been reported mainly after short-term medical antireflux therapy, and few individual lesions have been examined. We report detailed histological findings from the LOTUS study, at baseline and at 1 and 3 years after laparoscopic antireflux surgery (LARS) or esomeprazole treatment in patients with chronic GERD.
Original languageEnglish
JournalAmerican Journal of Gastroenterology
Pages (from-to)1015-23
Number of pages9
Publication statusPublished - 1 May 2010

    Research areas

  • Adult, Age Distribution, Biopsy, Needle, Chronic Disease, Esophageal pH Monitoring, Esophagitis, Peptic, Esophagoscopy, Female, Follow-Up Studies, Fundoplication, Gastroesophageal Reflux, Humans, Immunohistochemistry, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Omeprazole, Probability, Risk Assessment, Severity of Illness Index, Sex Distribution, Statistics, Nonparametric, Time Factors, Treatment Outcome

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