miRConnect 2.0: identification of oncogenic, antagonistic miRNA families in three human cancers

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DOI

  • Youjia Hua, Feinberg School of Medicine, Division Hematology/Oncology, Northwestern University, United States
  • Niels Larsen
  • Shanker Kalyana-Sundaram, 3 Michigan Center for Translational Pathology, United States
  • Jørgen Kjems
  • Arul M Chinnaiyan, Michigan Center for Translational Pathology, United States
  • Marcus E Peter, Feinberg School of Medicine, Division Hematology/Oncology, Northwestern University, United States
Based on their function in cancer micro(mi)RNAs are often grouped as either tumor suppressors or oncogenes. However, miRNAs regulate multiple tumor relevant signaling pathways raising the question whether two oncogenic miRNAs could be functional antagonists by promoting different steps in tumor progression. We recently developed a method to connect miRNAs to biological function by comparing miRNA and gene array expression data from the NCI60 cell lines without using miRNA target predictions (miRConnect).
Original languageEnglish
JournalB M C Genomics
Volume14
Issue179
Pages (from-to)1-18
Number of pages18
ISSN1471-2164
DOIs
Publication statusPublished - 15 Mar 2013

    Research areas

  • Carcinoma, Renal Cell, Cell Line, Tumor, Cluster Analysis, Epithelial-Mesenchymal Transition, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Glioblastoma, Humans, Kidney Neoplasms, MicroRNAs, Neoplasms, Oncogenes, Ovarian Neoplasms, RNA, Messenger

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