Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative Disorders

Publication: Research - peer-reviewJournal article

  • Amin Mottahedin
    Amin Mottahedin
  • Maryam Ardalan
  • Tetyana Chumak
    Tetyana Chumak
  • Ilse Riebe
    Ilse Riebe
  • Joakim Ek
    Joakim Ek
  • Carina Mallard
    Carina Mallard
The brain is a plastic organ where both the intrinsic CNS milieu and extrinsic cues play important roles in shaping and wiring neural connections. The perinatal period constitutes a critical time in central nervous system development with extensive refinement of neural connections, which are highly sensitive to fetal and neonatal compromise, such as inflammatory challenges. Emerging evidence suggests that inflammatory cells in the brain such as microglia and astrocytes are pivotal in regulating synaptic structure and function. In this article, we will review the role of glia cells in synaptic physiology and pathophysiology, including microglia-mediated elimination of synapses. We propose that activation of the immune system dynamically affects synaptic organization and function in the developing brain. We will discuss the role of neuroinflammation in altered synaptic plasticity following perinatal inflammatory challenges and potential implications for neurodevelopmental and neurodegenerative disorders.
Original languageEnglish
JournalFrontiers in cellular neuroscience
Volume11
ISSN1662-5102
StatePublished - 11 Jul 2017

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