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Does vagotomy protect against multiple sclerosis?

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OBJECTIVES: To examine the association between vagotomy and multiple sclerosis.

METHODS: We conducted a matched cohort study of all patients who underwent truncal or super-selective vagotomy and a comparison cohort, by linking Danish population-based medical registries (1977-1995). Hazard ratios (HRs) for multiple sclerosis, adjusting for potential confounders were computed by means of Cox regression analysis.

RESULTS: Median age of multiple sclerosis onset corresponded to late onset multiple sclerosis. No association with multiple sclerosis was observed for truncal vagotomy (0-37 year adjusted HR=0.91, 95% confidence interval [CI]: 0.48-1.74) or super-selective vagotomy (0-37 year adjusted HR=1.28, 95% CI: 0.79-2.09) compared with the general population.

INTERPRETATION: We found no association between vagotomy and later risk of late onset multiple sclerosis.

Original languageEnglish
JournalMultiple Sclerosis and Related Disorders
Volume15
Pages (from-to)34-36
Number of pages3
ISSN2211-0348
DOIs
Publication statusPublished - Jul 2017

    Research areas

  • Journal Article

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