Matrix metalloproteinase-8 overexpression prevents proper tissue repair

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Patricia Louise Danielsen
  • ,
  • Anders V Holst
  • ,
  • Henrik R Maltesen
  • ,
  • Maria Rosaria Bassi
  • ,
  • Peter J Holst
  • ,
  • Katja M Heinemeier
  • ,
  • Jørgen Olsen
  • ,
  • Carl Christian Danielsen
  • Steen S Poulsen, Denmark
  • Lars N Jorgensen
  • ,
  • Magnus S Agren
The collagenolytic matrix metalloproteinase-8 (MMP-8) is essential for normal tissue repair but is often overexpressed in wounds with disrupted healing. Our aim was to study the impact of a local excess of this neutrophil-derived proteinase on wound healing using recombinant adenovirus-driven transduction of full-length Mmp8 (AdMMP-8).
Original languageEnglish
JournalSurgery
Volume150
Issue5
Pages (from-to)897-906
Number of pages10
ISSN0263-9319
DOIs
Publication statusPublished - 27 Aug 2011

    Research areas

  • Adenoviridae, Animals, Cells, Cultured, Collagen, Dermis, Disease Models, Animal, Fibroblasts, Gene Expression Regulation, Enzymologic, Granulation Tissue, Macrophages, Male, Matrix Metalloproteinase 8, Neutrophils, Rats, Rats, Wistar, Wound Healing

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