The effect of crack cocaine addiction on the microstructure and morphology of the human striatum and thalamus using novel shape analysis and fast diffusion kurtosis imaging.

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  • Eduardo A. Garza-Villarreal
  • Chakravarty Mallar, Department of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Quebec, Canada H4H 1R3.,
  • Brian Hansen
  • Simon Fristed Eskildsen
  • Gabriel A. Devenyi, Department of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Quebec, Canada H4H 1R3., CanadaDiana Castillo-Padilla, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", MexicoThania Balducci-Garcia, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", MexicoErnesto Reyes-Zamorano, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Mexico
  • Sune Nørhøj Jespersen
  • Pamela Perez-Palacios, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", MexicoRaihaan Patel, Department of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Quebec, Canada H4H 1R3., CanadaJorge J. Gonzalez-Olvera, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Mexico
The striatum and thalamus are subcortical structures intimately involved in addiction, and the morphology and microstructure of these has been studied in murine models of cocaine addiction. However, human studies using non-invasive MRI has shown inconsistencies in morphology using volumetric analysis. In our study, we used MRI-based volumetric and novel shape analysis, as well as a novel fast diffusion kurtosis imaging sequence to study the morphology and microstructure of striatum and thalamus in crack cocaine addiction (CA) compared to matched healthy controls (HC). We did not find significant differences in volume and mean kurtosis (MKT) between groups. However, we found significant contraction of nucleus accumbens in CA compared to HC. We also found significant age related changes in volume and MKT of CA in striatum and thalamus that are contrary to those seen in normal brain aging. Our findings suggest that the use of finer methods and sequences is needed to characterize morphological and microstructural changes in cocaine addiction, and that brain changes in cocaine addiction are related to age.
Original languageEnglish
Article number066647
JournalbioRxiv
Issue number066647
DOIs
StatePublished - 29 Jul 2016

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    Research areas

  • Addiction, MORPHOLOGY, Cocaine-Related Disorders, MRI

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