The effect of crack cocaine addiction on the microstructure and morphology of the human striatum and thalamus using novel shape analysis and fast diffusion kurtosis imaging.

Research output: ResearchJournal article

  • Eduardo A. Garza-Villarreal
  • Chakravarty Mallar
    Chakravarty MallarDepartment of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Quebec, Canada H4H 1R3.
  • Brian Hansen
  • Simon Fristed Eskildsen
  • Gabriel A. Devenyi
    Gabriel A. DevenyiDepartment of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Quebec, Canada H4H 1R3.Canada
  • Diana Castillo-Padilla
    Diana Castillo-PadillaInstituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz"Mexico
  • Thania Balducci-Garcia
    Thania Balducci-GarciaInstituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz"Mexico
  • Ernesto Reyes-Zamorano
    Ernesto Reyes-ZamoranoInstituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz"Mexico
  • Sune Nørhøj Jespersen
  • Pamela Perez-Palacios
    Pamela Perez-PalaciosInstituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz"Mexico
  • Raihaan Patel
    Raihaan PatelDepartment of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Quebec, Canada H4H 1R3.Canada
  • Jorge J. Gonzalez-Olvera
    Jorge J. Gonzalez-OlveraInstituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz"Mexico
The striatum and thalamus are subcortical structures intimately involved in addiction, and the morphology and microstructure of these has been studied in murine models of cocaine addiction. However, human studies using non-invasive MRI has shown inconsistencies in morphology using volumetric analysis. In our study, we used MRI-based volumetric and novel shape analysis, as well as a novel fast diffusion kurtosis imaging sequence to study the morphology and microstructure of striatum and thalamus in crack cocaine addiction (CA) compared to matched healthy controls (HC). We did not find significant differences in volume and mean kurtosis (MKT) between groups. However, we found significant contraction of nucleus accumbens in CA compared to HC. We also found significant age related changes in volume and MKT of CA in striatum and thalamus that are contrary to those seen in normal brain aging. Our findings suggest that the use of finer methods and sequences is needed to characterize morphological and microstructural changes in cocaine addiction, and that brain changes in cocaine addiction are related to age.
Original languageEnglish
Article number066647
JournalbioRxiv
Issue number066647
DOIs
StatePublished - 29 Jul 2016

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    Research areas

  • Addiction, MORPHOLOGY, Cocaine-Related Disorders, MRI

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