Early onset type 2 diabetes: Age gradient in Clinical and Behavioural Risk Factors in 5115 Persons with Newly Diagnosed Type 2 Diabetes - Results from the DD2 study

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  • A Bo
  • R W Thomsen
  • J S Nielsen, Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Odense, Denmark.,
  • S K Nicolaisen
  • H Beck-Nielsen, Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Odense, Denmark.,
  • J Rungby
  • H T Sørensen
  • T K Hansen
  • J Søndergaard, Research Unit for General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark., S Friborg, Endokrinologisk Afdeling M, Odense Universitetshospital, Denmark
  • T Lauritzen
  • H T Maindal
AIM: To examine the association between early onset of type 2 diabetes (DM) and clinical and behavioural risk factors for later diabetes complications. METHODS: We conducted a cross-sectional study of 5115 persons with incident type 2 DM enrolled during 2010-2015 in the Danish Centre for Strategic Research in Type 2 Diabetes-cohort. We compared risk factors at time of diagnosis among those diagnosed at ≤45 years (early-onset) with diagnosis age 46-55, 56-65 (average-onset = reference), 66-75, and >75 years (late-onset). Prevalence ratios (PRs) were computed using Poisson regression. RESULTS: Poor glucose control i.e. HbA1c≥75 mmol/mol (≥9.0%) in the early-, average-, and late-onset groups was observed in 12%, 7%, and 1% respectively [PR 1.70 (95% confidence intervals (CI) 1.27, 2.28) and PR 0.17 (95% CI 0.06, 0.45)]. A similar age gradient was observed for severe obesity [BMI>40 kg/m2 : 19% vs. 8% vs. 2%; PR 2.41 (95% CI 1.83, 3.18) and 0.21 (95% CI 0.08, 0.57)], dyslipidemia [90% vs. 79% vs. 68%; PR 1.14 (95% CI 1.10, 1.19) and 0.86 (95% CI 0.79, 0.93)], and low-grade inflammation [CRP>3.0 mg/L: 53% vs. 38% vs. 26%; PR 1.41 (95% CI 1.12, 1.78) and 0.68 (95% CI 0.42, 1.11)]. Daily smoking was more frequent and meeting physical activity recommendations less likely in persons with early-onset type 2 DM. CONCLUSIONS: We found a clear age-gradient, with increasing prevalence of clinical and behavioural risk factors the younger the onset age of type 2 DM. Younger persons with early-onset type 2 DM need clinical awareness and support.
Translated title of the contributionTidligt indsættende type 2 diabetes: Aldersgradient i kliniske og adfærdsmæssige risikofaktorer blandt 5115 personer nyligt diagnosticeret med type 2 diabetes - resultater fra DD2 studiet
Original languageEnglish
Article numbere2968
JournalDiabetes - Metabolism: Research and Reviews
Issue number3
Number of pages9
Publication statusPublished - Mar 2018

    Research areas

  • Journal Article, cross sections study, DD2 study, early onset type 2 diabetes, health behaviour, risk factors

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