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Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes: analysis of the ADDITION-UK cluster-randomized controlled trial

Publication: Research - peer-reviewJournal article

DOI

  • L Tao
    L TaoUnited Kingdom
  • E C F Wilson
    E C F WilsonUnited Kingdom
  • N J Wareham
    N J WarehamUnited Kingdom
  • A Sandbaek
  • G E H M Rutten
    G E H M RuttenNetherlands
  • T Lauritzen
  • K Khunti
    K KhuntiUnited Kingdom
  • M J Davies
    M J DaviesUnited Kingdom
  • K Borch-Johnsen
    K Borch-JohnsenSektion for Almen Medicin, Institut for FolkesundhedHolbæk SygehusDenmark
  • S J Griffin
    S J GriffinUnited Kingdom
  • Rebecca Simmons
Aims
To examine the short- and long-term cost-effectiveness of intensive multifactorial treatment compared with routine care among people with screen-detected Type 2 diabetes.

Methods
Cost–utility analysis in ADDITION-UK, a cluster-randomized controlled trial of early intensive treatment in people with screen-detected diabetes in 69 UK general practices. Unit treatment costs and utility decrement data were taken from published literature. Accumulated costs and quality-adjusted life years (QALYs) were calculated using ADDITION-UK data from 1 to 5 years (short-term analysis, n = 1024); trial data were extrapolated to 30 years using the UKPDS outcomes model (version 1.3) (long-term analysis; n = 999). All costs were transformed to the UK 2009/10 price level.

Results
Adjusted incremental costs to the NHS were £285, £935, £1190 and £1745 over a 1-, 5-, 10- and 30-year time horizon, respectively (discounted at 3.5%). Adjusted incremental QALYs were 0.0000, – 0.0040, 0.0140 and 0.0465 over the same time horizons. Point estimate incremental cost-effectiveness ratios (ICERs) suggested that the intervention was not cost-effective although the ratio improved over time: the ICER over 10 years was £82 250, falling to £37 500 over 30 years. The ICER fell below £30 000 only when the intervention cost was below £631 per patient: we estimated the cost at £981.

Conclusion
Given conventional thresholds of cost-effectiveness, the intensive treatment delivered in ADDITION was not cost-effective compared with routine care for individuals with screen-detected diabetes in the UK. The intervention may be cost-effective if it can be delivered at reduced cost.
Original languageEnglish
JournalDiabetic medicine : a journal of the British Diabetic Association
Volume32
Issue number7
Pages (from-to)907-19
Number of pages13
ISSN1464-5491
DOIs
StatePublished - Jul 2015

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