5-HT1A receptors in lithium-induced conditioned taste aversion

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Experiments were carried out using rats to investigate whether 5-HT1A neural mechanisms are involved in lithium-induced conditioned taste aversion (CTA). We found that the 5-HT1A antagonists p-MPPI and pindolol caused CTA similar to that produced by LiCl. The 5-HT1A agonist 8-OH-DPAT counteracted lithium-induced CTA. Pindolol dose-dependently abolished effects of 8-OH-DPAT on LiCl-induced CTA. These findings support the notion that lithium has antagonistic actions on 5-HT1A receptors. Inhibition of 5-HT synthesis by PCPA failed, however, to prevent lithium-induced CTA. Evidently, mechanisms other than those governed solely by 5-HT are also involved in lithium-induced CTA.
Original languageEnglish
JournalPsychopharmacology
Volume133
Issue1
Pages (from-to)51-4
Number of pages4
ISSN0033-3158
Publication statusPublished - 1997

    Research areas

  • 8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Body Temperature, Feeding Behavior, Lithium, Male, Pindolol, Rats, Receptors, Serotonin, Receptors, Serotonin, 5-HT1, Saccharin, Taste

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