Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

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  • Benjamin F Voight
  • ,
  • Laura J Scott
  • ,
  • Valgerdur Steinthorsdottir
  • ,
  • Andrew P Morris
  • ,
  • Christian Dina
  • ,
  • Ryan P Welch
  • ,
  • Eleftheria Zeggini
  • ,
  • Cornelia Huth
  • ,
  • Yurii S Aulchenko
  • ,
  • Gudmar Thorleifsson
  • ,
  • Laura J McCulloch
  • ,
  • Teresa Ferreira
  • ,
  • Harald Grallert
  • ,
  • Najaf Amin
  • ,
  • Guanming Wu
  • ,
  • Cristen J Willer
  • ,
  • Soumya Raychaudhuri
  • ,
  • Steve A McCarroll
  • ,
  • Claudia Langenberg
  • ,
  • Oliver M Hofmann
  • Josée Dupuis
  • ,
  • Lu Qi
  • ,
  • Ayellet V Segrè
  • ,
  • Mandy van Hoek
  • ,
  • Pau Navarro
  • ,
  • Kristin Ardlie
  • ,
  • Beverley Balkau
  • ,
  • Rafn Benediktsson
  • ,
  • Amanda J Bennett
  • ,
  • Roza Blagieva
  • ,
  • Eric Boerwinkle
  • ,
  • Lori L Bonnycastle
  • ,
  • Kristina Bengtsson Boström
  • ,
  • Bert Bravenboer
  • ,
  • Suzannah Bumpstead
  • ,
  • Noisël P Burtt
  • ,
  • Guillaume Charpentier
  • ,
  • Peter S Chines
  • ,
  • Marilyn Cornelis
  • ,
  • David J Couper
  • ,
  • Gabe Crawford
  • ,
  • Alex S F Doney
  • ,
  • Katherine S Elliott
  • ,
  • Amanda L Elliott
  • ,
  • Michael R Erdos
  • ,
  • Caroline S Fox
  • ,
  • Christopher S Franklin
  • ,
  • Martha Ganser
  • ,
  • Christian Gieger
  • ,
  • Torsten Lauritzen
  • MAGIC investigators
  • Institute of General Medical Practice
  • Nyremedicinsk Afdeling, Medicinsk Center, Aalborg Sygehus Syd
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P
Original languageEnglish
JournalNature Genetics
Volume42
Issue7
Pages (from-to)579-89
Number of pages11
ISSN1061-4036
DOIs
Publication statusPublished - 1 Jul 2010

    Research areas

  • Blood Glucose, Diabetes Mellitus, Type 2, Dual-Specificity Phosphatases, Fasting, Gene Dosage, Gene Expression Profiling, Genetic Heterogeneity, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Hepatocyte Nuclear Factor 1-alpha, Humans, KCNQ1 Potassium Channel, Meta-Analysis as Topic, Mitogen-Activated Protein Kinase Phosphatases, Polymorphism, Single Nucleotide

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