Cancer mortality in an international cohort of workers exposed to styrene.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • M. Kogevinas, International Agency for Research on Cancer
  • ,
  • G. Ferro, International Agency for Research on Cancer
  • ,
  • R. Saracci, International Agency for Research on Cancer
  • ,
  • A. Andersen, International Agency for Research on Cancer
  • ,
  • M. Biocca, International Agency for Research on Cancer
  • ,
  • D. Coggon, International Agency for Research on Cancer
  • ,
  • V. Gennaro, International Agency for Research on Cancer
  • ,
  • S. Hutchings, International Agency for Research on Cancer
  • ,
  • H. Kolstad
  • I. Lundberg

Increased risks for leukaemia and lymphoma have been suggested in studies of workers exposed to styrene in the rubber and plastics industry. A historical cohort study was conducted in Denmark, Finland, Italy, Norway, Sweden and the United Kingdom involving 40,683 workers employed in the reinforced plastics industry, where high exposure to styrene occurs. Exposure to styrene was reconstructed through job histories, environmental and biological monitoring data and production records of the plants in the study. Cause-specific national death rates were used as the reference. Among exposed workers, no excess was observed for mortality from all causes (2195 deaths, standardized mortality ratio [SMR], 95; 95% confidence interval [CI], 91-99), from all neoplasms, from lung cancer or from other major epithelial cancers. Mortality from neoplasms of the lymphatic and haematopoietic tissues was not elevated (50 deaths; SMR, 96; CI, 71-126) and was not consistently associated with length of exposure. The rate of mortality from leukaemias and lymphomas increased with time since first exposure. Among subjects who had been exposed for more than one year, a two-fold risk was observed 20 years after first exposure (eight deaths; SMR, 197; CI, 85-387). These results are inadequate to exclude the possibility that styrene causes leukaemia and lymphoma.

Original languageEnglish
Book seriesIARC scientific publications
Issue127
Pages (from-to)289-300
Number of pages12
ISSN0300-5038
Publication statusPublished - 1 Dec 1993

See relations at Aarhus University Citationformats

ID: 132197390