Reappraisal of the regulation of lactococcal L-lactate dehydrogenase

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  • Ed W J van Niel, Denmark
  • Johan Palmfeldt
  • Rani Martin, Denmark
  • Marco Paese, Denmark
  • Bärbel Hahn-Hägerdal, Denmark
Lactococcal lactate dehydrogenases (LDHs) are coregulated at the substrate level by at least two mechanisms: the fructose-1,6-biphosphate/phosphate ratio and the NADH/NAD ratio. Among the Lactococcus lactis species, there are strains that are predominantly regulated by the first mechanism (e.g., strain 65.1) or by the second mechanism (e.g., strain NCDO 2118). A more complete model of the kinetics of the regulation of lactococcal LDH is discussed.
Original languageEnglish
JournalApplied and Environmental Microbiology
Volume70
Issue3
Pages (from-to)1843-6
Number of pages3
ISSN0099-2240
Publication statusPublished - 2004
Externally publishedYes

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