Immunoglobulin deposits in peripheral nerve endings detected by skin biopsy in patients with IgM M proteins and neuropathy

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • V Jønsson
  • ,
  • T S Jensen
  • M L Friis
  • ,
  • H D Schrøder
  • ,
  • B Stigsby
  • ,
  • J Struck
  • ,
  • E Hippe
  • ,
  • W Trojaborg, Denmark

Immunofluorescence studies of sural nerve and skin biopsies from three patients with IgM M proteins and clinical neuropathy showed that IgM M protein was bound to the nerve myelin in two patients and by the peri- and endoneurium in one. It is suggested that immunohistochemical studies of skin biopsies provide a simple effective method of detecting immunoglobulin binding to peripheral nerves in patients suspected of having an autoimmune neuropathy. In contrast to sural nerve biopsy, skin biopsy does not cause sensory loss or pain in a denervated area and can easily be repeated.

Original languageEnglish
JournalNeurology
Volume37
Issue2
Pages (from-to)303-6
Number of pages4
ISSN0028-3878
Publication statusPublished - Feb 1987

    Research areas

  • Aged, Autoimmune Diseases, Glycoproteins, Humans, Immunoglobulin M, Male, Middle Aged, Nerve Endings, Peripheral Nervous System Diseases, Skin

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