Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands

Publication: Research - peer-reviewJournal article

DOI

  • Jacob Andersen
    Jacob AndersenUniversity of Copenhagen
  • Lucy Kate Ladefoged
  • Trine N. Bjerre Kristensen
  • Lachlan Munro
    Lachlan MunroUniversity of Copenhagen
  • Julie Grouleff
    Julie Grouleff
  • Nicolai Stuhr-Hansen
    Nicolai Stuhr-HansenUniversity of Copenhagen
  • Anders S. Kristensen
    Anders S. KristensenUniversity of CopenhagenDenmark
  • Birgit Schiott
  • Kristian Strømgaard
    Kristian StrømgaardUniversity of CopenhagenDenmark
Original languageEnglish
JournalACS Chemical Neuroscience
Volume7
Issue number10
Pages (from-to)1406-1417
Number of pages12
ISSN1948-7193
DOIs
StatePublished - Oct 2016

    Keywords

  • Serotonin transporter, dopamine transporter, alternating access mechanism, neurotransmitter transport, molecular pharmacology, induced-fit docking, NEUROTRANSMITTER-SODIUM SYMPORTER, ANTIDEPRESSANT BINDING-SITE, X-RAY STRUCTURES, REUPTAKE INHIBITORS, MONOAMINE TRANSPORTERS, S2 SITE, NOREPINEPHRINE TRANSPORTERS, BACTERIAL HOMOLOG, LEUT, MECHANISM

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ID: 104562132