The high-risk plaque initiative: primary prevention of atherothrombotic events in the asymptomatic population

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  • Erling Falk
  • Henrik Sillesen, Kirurgi og Intern Medicin, Denmark
  • Pieter Muntendam
  • ,
  • Valentin Fuster
The High-Risk Plaque (HRP) Initiative is a research and development effort to advance the understanding, recognition, and management of asymptomatic individuals at risk for a near-term atherothrombotic event such as myocardial infarction or stroke. Clinical studies using the newest technologies have been initiated, including the BioImage Study in which novel approaches are tested in a typical health plan population. Asymptomatic at-risk individuals were enrolled, including a survey-only group (n = 865), a group undergoing traditional risk factor scoring (n = 718), and a group in which all were assessed for both risk factors and subclinical atherosclerosis (n = 6104). The latter two groups underwent baseline examination in a dedicated mobile facility equipped with advanced imaging tools suitable for noninvasive screening for subclinical atherosclerosis (coronary artery calcium by computed tomography [CT], carotid and aortic disease by ultrasound, and ankle-brachial index). Selected participants were offered advanced imaging (contrast-enhanced CT, magnetic resonance imaging, and positron emission tomography/CT). Plasma, PAXgene RNA, and DNA samples were obtained for biomarker discovery studies. All individuals will be followed until 600 major atherothrombotic events have occurred in those undergoing imaging.
Original languageEnglish
JournalCurrent Atherosclerosis Reports
Pages (from-to)359-66
Number of pages8
Publication statusPublished - 2011

    Research areas

  • Aged, Aged, 80 and over, Atherosclerosis, Biological Markers, Diagnostic Imaging, Female, Humans, Male, Managed Care Programs, Mass Screening, Middle Aged, Myocardial Infarction, Predictive Value of Tests, Primary Prevention, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Stroke, United States

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