Application of Methyl Bisphosphine-Ligated Palladium Complexes for Low Pressure N-11C-Acetylation of Peptides

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DOI

A mild and effective method is described for C-11-labeling of peptides selectively at the N-terminal nitrogen or at internal lysine positions. The presented method relies on the use of specific biphosphine palladium-methyl complexes and their high reactivity towards amino-carbonylation of amine groups in the presence [C-11] carbon monoxide. The protocol facilitates the production of native N-C-11-acetylated peptides, without any structural modifications and has been applied to a selection of bioactive peptides.

Original languageEnglish
JournalAngewandte Chemie International Edition
Volume56
Issue16
Pages (from-to)4549-4553
Number of pages5
ISSN1433-7851
DOIs
Publication statusPublished - 10 Apr 2017

    Research areas

  • C-11-labeling, carbonylation, palladium, peptides, CARBONYLATION REACTIONS, CARBON-MONOXIDE, ANTIMICROBIAL PEPTIDES, RADIOLABELED PEPTIDES, PET, RADIOPHARMACEUTICALS, PEPTAIBOLS, ANALOGS, SCOPE, CYCLOISOMERIZATION

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