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Ex-vivo diffusion MRI reveals microstructural alterations in stress-sensitive brain regions: A chronic mild stress recovery study

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  • Ahmad Raza Khan
  • Brian Hansen
  • Ove Wiborg, Denmark
  • Christopher Kroenke, Department of Behavioral Neuroscience, Advanced Imaging Research Center, Oregon Health and Science University, United States
  • Sune Jespersen
Depression is a leading cause of disability worldwide and causes significant microstructural alterations in stress-sensitive brain regions.
However, the potential recovery of these microstructural alterations has not previously been investigated, which we, therefore, set out to do
using diffusion MRI (d-MRI) in the chronic mild stress (CMS) rat model of depression. This study reveals significant microstructural alterations
after 8 weeks of recovery, in the opposite direction to change induced by stress in the acute phase of the experiment. Such findings may be
useful in the prognosis of depression or for monitoring treatment response.
Original languageEnglish
Publication year2 Feb 2018
Publication statusPublished - 2 Feb 2018
EventJoint ISMRM and ESMRMB conference, Paris - Paris, Paris, France
Duration: 16 Jun 201821 Jun 2018


ConferenceJoint ISMRM and ESMRMB conference, Paris

    Research areas

  • Depression, Diffusion MRI, Hippocampus

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